| Reaction Details |
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 | Report a problem with these data |
| Target | Vasopressin V1b receptor |
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| Ligand | BDBM50325847 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_652648 (CHEMBL1225851) |
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| IC50 | 210±n/a nM |
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| Citation |  Letourneau, JJ; Riviello, CM; Li, H; Cole, AG; Ho, KK; Zanetakos, HA; Desai, H; Zhao, J; Auld, DS; Napier, SE; Thomson, FJ; Goan, KA; Morphy, JR; Ohlmeyer, MH; Webb, ML Identification and optimization of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V3 (V1b) receptor antagonists. Bioorg Med Chem Lett20:5394-7 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Vasopressin V1b receptor |
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| Name: | Vasopressin V1b receptor |
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| Synonyms: | Avpr1b | V1BR_RAT | VASOPRESSIN V1B | Vasopressin V1b receptor | Vasopressin receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 47104.48 |
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| Organism: | RAT |
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| Description: | VASOPRESSIN V1B AVPR1B RAT::P48974 |
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| Residue: | 425 |
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| Sequence: | MNSEPSWTATPSPGGTLPVPNATTPWLGRDEELAKVEIGILATVLVLATGGNLAVLLTLG
RHGHKRSRMHLFVLHLALTDLGVALFQVLPQLLWDITYRFQGSDLLCRAVKYLQVLSMFA
STYMLLAMTLDRYLAVCHPLRSLRQPSQSTYPLIAAPWLLAAILSLPQVFIFSLREVIQG
SGVLDCWADFYFSWGPRAYITWTTMAIFVLPVAVLSACYGLICHEIYKNLKVKTQAGREE
RRGWRTWDKSSSSAVATAATRGLPSRVSSISTISRAKIRTVKMTFVIVLAYIACWAPFFS
VQMWSVWDENAPNEDSTNVAFTISMLLGNLSSCCNPWIYMGFNSRLLPRSLSHHACCTGS
KPQVHRQLSTSSLTSRRTTLLTHACGSPTLRLSLNLSLRAKPRPAGSLKDLEQVDGEATM
ETSIF
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| BDBM50325847 |
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| n/a |
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| Name | BDBM50325847 |
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| Synonyms: | CHEMBL1223814 | N-(cyclopropylmethyl)-2-(6-(3-morpholinopropoxy)-4-oxo-2-phenylquinazolin-3(4H)-yl)acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C27H32N4O4 |
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| Mol. Mass. | 476.5674 |
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| SMILES | O=C(Cn1c(nc2ccc(OCCCN3CCOCC3)cc2c1=O)-c1ccccc1)NCC1CC1 |
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| Structure | 
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