| Reaction Details |
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 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
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| Ligand | BDBM50326887 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_662962 (CHEMBL1250821) |
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| Ki | 4400±n/a nM |
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| Citation |  Giordano, C; Sansone, A; Masi, A; Lucente, G; Punzi, P; Mollica, A; Pinnen, F; Feliciani, F; Cacciatore, I; Davis, P; Lai, J; Ma, SW; Porreca, F; Hruby, V Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2. Eur J Med Chem45:4594-600 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kappa-type opioid receptor |
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| Name: | Kappa-type opioid receptor |
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| Synonyms: | KOR-1 | Kappa Opioid Receptor | OPIATE Kappa | OPRK_RAT | Opioid receptor | Oprk1 | Ror-d |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42692.90 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P34975 |
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| Residue: | 380 |
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| Sequence: | MESPIQIFRGEPGPTCAPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAVLSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRV
RNTVQDPASMRDVGGMNKPV
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| BDBM50326887 |
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| n/a |
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| Name | BDBM50326887 |
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| Synonyms: | (R)-1-((S)-2-(2-((S)-1-((S)-2-amino-3-(4-hydroxyphenyl)propanoyl)pyrrolidin-2-yl)acetamido)-3-phenylpropanoyl)pyrrolidine-2-carboxamide | CHEMBL1254974 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H37N5O5 |
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| Mol. Mass. | 535.6346 |
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| SMILES | N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1CC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@@H]1C(N)=O |r| |
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| Structure | 
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