| Reaction Details |
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 | Report a problem with these data |
| Target | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase |
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| Ligand | BDBM50329257 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_675154 (CHEMBL1273011) |
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| Ki | 4800±n/a nM |
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| Citation |  Tasdemir, D; Sanabria, D; Lauinger, IL; Tarun, A; Herman, R; Perozzo, R; Zloh, M; Kappe, SH; Brun, R; Carballeira, NM 2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections. Bioorg Med Chem18:7475-85 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 3-hydroxyacyl-[acyl-carrier-protein] dehydratase |
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| Name: | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase |
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| Synonyms: | Fatty acid synthase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 26222.50 |
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| Organism: | Plasmodium falciparum |
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| Description: | ChEMBL_983601 |
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| Residue: | 230 |
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| Sequence: | MRFLIIHIAVIVLPFVLMIDVKRENSFFLRHSPKRLYKKADYNNMYDKIIKKQQNRIYDV
SSQINQDNINGQNISFNLTFPNYDTSIDIEDIKKILPHRYPFLLVDKVIYMQPNKTIIGL
KQVSTNEPFFNGHFPQKQIMPGVLQIEALAQLAGILCLKSDDSQKNNLFLFAGVDGVRWK
KPVLPGDTLTMQANLISFKSSLGIAKLSGVGYVNGKVVINISEMTFALSK
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| BDBM50329257 |
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| n/a |
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| Name | BDBM50329257 |
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| Synonyms: | 2-Hexadecynoic acid | CHEMBL1269411 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H30O2 |
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| Mol. Mass. | 266.4189 |
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| SMILES | CCCCCCCCCCCCCCC#CC(O)=O |
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| Structure | 
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