Reaction Details | |||
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Target | Bcl-2-like protein 1 | ||
Ligand | BDBM50330255 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_676275 (CHEMBL1273516) | ||
Ki | 960±n/a nM | ||
Citation | Wei, J; Kitada, S; Stebbins, JL; Placzek, W; Zhai, D; Wu, B; Rega, MF; Zhang, Z; Cellitti, J; Yang, L; Dahl, R; Reed, JC; Pellecchia, M Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. J Med Chem53:8000-11 (2010) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Bcl-2-like protein 1 | |||
Name: | Bcl-2-like protein 1 | ||
Synonyms: | Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD) | ||
Type: | Mitochondrion membrane; Single-pass membrane protein | ||
Mol. Mass.: | 26039.60 | ||
Organism: | Homo sapiens (Human) | ||
Description: | n/a | ||
Residue: | 233 | ||
Sequence: |
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BDBM50330255 | |||
n/a | |||
Name | BDBM50330255 | ||
Synonyms: | 6,6',7,7'-Tetrahydroxy-3,3'-dimethyl-5,5'-bis(3-phenylpropyl)-2,2'-binaphthyl-1,1',4,4'-tetraone | CHEMBL1269077 | ||
Type | Small organic molecule | ||
Emp. Form. | C40H34O8 | ||
Mol. Mass. | 642.6932 | ||
SMILES | Oc1cc2c(O)c(-c3c(O)c4cc(O)c(O)c(=CCCc5ccccc5)c4c(O)c3=C)c(=C)c(O)c2c(=CCCc2ccccc2)c1O |w:37.41,17.17,(4.3,-20.93,;5.64,-21.7,;6.97,-20.92,;8.31,-21.7,;9.65,-20.92,;9.64,-19.38,;10.99,-21.69,;12.32,-20.93,;13.66,-21.7,;13.65,-23.24,;14.98,-20.94,;16.3,-21.72,;17.65,-20.97,;18.98,-21.75,;17.67,-19.42,;19.01,-18.67,;16.33,-18.63,;16.35,-17.09,;17.69,-16.33,;17.7,-14.79,;19.04,-14.04,;20.36,-14.82,;21.7,-14.07,;21.71,-12.52,;20.38,-11.74,;19.04,-12.51,;14.99,-19.4,;13.66,-18.62,;13.67,-17.08,;12.32,-19.39,;10.99,-18.62,;10.99,-23.24,;12.33,-24.01,;9.65,-24.01,;9.65,-25.55,;8.32,-23.24,;6.97,-24.01,;6.97,-25.55,;5.63,-26.32,;5.63,-27.86,;4.3,-28.63,;2.97,-27.85,;1.63,-28.62,;1.63,-30.16,;2.97,-30.93,;4.3,-30.16,;5.64,-23.24,;4.3,-24.01,)| | ||
Structure |