Reaction Details |
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Target | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial |
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Ligand | BDBM50333016 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_689885 (CHEMBL1633334) |
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IC50 | >50000±n/a nM |
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Citation | Barile, E; De, SK; Carlson, CB; Chen, V; Knutzen, C; Riel-Mehan, M; Yang, L; Dahl, R; Chiang, G Design, Synthesis, and Structure−Activity Relationships of 3-Ethynyl-1H-indazoles as Inhibitors of the Phosphatidylinositol 3-Kinase Signaling Pathway J Med Chem53:8368-8375 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial |
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Name: | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial |
Synonyms: | PDHK1 | PDK1 | PDK1_HUMAN | Pyruvate dehydrogenase kinase | Pyruvate dehydrogenase kinase 1 (PDK1) | Pyruvate dehydrogenase kinase isoform 1 |
Type: | Protein |
Mol. Mass.: | 49255.23 |
Organism: | Homo sapiens (Human) |
Description: | Q15118 |
Residue: | 436 |
Sequence: | MRLARLLRGAALAGPGPGLRAAGFSRSFSSDSGSSPASERGVPGQVDFYARFSPSPLSMK
QFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQE
LLDFKDKSAEDAKAIYDFTDTVIRIRNRHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYF
LDRFYMSRISIRMLLNQHSLLFGGKGKGSPSHRKHIGSINPNCNVLEVIKDGYENARRLC
DLYYINSPELELEELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHANRGVYPP
IQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLP
ISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTDSIERLPVYNKAAWKHYNTNHEADDW
CVPSREPKDMTTFRSA
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BDBM50333016 |
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n/a |
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Name | BDBM50333016 |
Synonyms: | 3-(Pyridin-2-ylethynyl)-1H-pyrazolo[3,4-b]pyridine | CHEMBL1631903 |
Type | Small organic molecule |
Emp. Form. | C13H8N4 |
Mol. Mass. | 220.2294 |
SMILES | c1cncc(c1)C#Cc1n[nH]c2ncccc12 |
Structure |
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