Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Histone deacetylase 11 |
---|
Ligand | BDBM50333088 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_690180 (CHEMBL1634310) |
---|
IC50 | 23±n/a nM |
---|
Citation | Auzzas, L; Larsson, A; Matera, R; Baraldi, A; Deschênes-Simard, B; Giannini, G; Cabri, W; Battistuzzi, G; Gallo, G; Ciacci, A; Vesci, L; Pisano, C Non-Natural Macrocyclic Inhibitors of Histone Deacetylases: Design, Synthesis, and Activity J Med Chem53:8387-8399 (2010) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Histone deacetylase 11 |
---|
Name: | Histone deacetylase 11 |
Synonyms: | HD11 | HDA11_HUMAN | HDAC11 | Human HDAC11 |
Type: | Chromatin regulator; hydrolase; repressor |
Mol. Mass.: | 39187.66 |
Organism: | Homo sapiens (Human) |
Description: | Q96DB2 |
Residue: | 347 |
Sequence: | MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSML
VEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG
TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL
DAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVER
NIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVT
SGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
|
|
|
BDBM50333088 |
---|
n/a |
---|
Name | BDBM50333088 |
Synonyms: | (S)-6-(19-Methoxy-11-oxo-3,13-dioxa-10-azatricyclo[15.3.1.04,9] henicosa-1(21),4(9),5,7,15,17,19-heptaen-12-yl)hexanoic acid hydroxyamide | CHEMBL1631914 |
Type | Small organic molecule |
Emp. Form. | C25H30N2O6 |
Mol. Mass. | 454.5155 |
SMILES | COc1cc2COc3ccccc3NC(=O)[C@H](CCCCCC(=O)NO)OC\C=C/c(c2)c1 |r,c:29| |
Structure |
|