| Reaction Details |
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 | Report a problem with these data |
| Target | Ribosomal protein S6 kinase beta-1 |
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| Ligand | BDBM50333468 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_698951 (CHEMBL1646055) |
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| IC50 | 521±n/a nM |
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| Citation |  Ye, P; Kuhn, C; Juan, M; Sharma, R; Connolly, B; Alton, G; Liu, H; Stanton, R; Kablaoui, NM Potent and selective thiophene urea-templated inhibitors of S6K. Bioorg Med Chem Lett21:849-52 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ribosomal protein S6 kinase beta-1 |
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| Name: | Ribosomal protein S6 kinase beta-1 |
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| Synonyms: | 70 kDa ribosomal protein S6 kinase 1 | 70 kDa ribosomal protein S6 kinase 1 (P70s6k) | 70 kDa ribosomal protein kinase (p70S6K) | KS6B1_HUMAN | Protein kinase 70S6K (T412E) | RAC-alpha serine/threonine-protein kinase/Ribosomal protein S6 kinase beta-1 | RPS6KB1 | Ribosomal protein S6 kinase (P70S6K) | Ribosomal protein S6 kinase I | S6K1 | STK14A | p70 S6 ribosomal protein kinase 1 | p70S6K1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 59139.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | His-tagged S6K1. |
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| Residue: | 525 |
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| Sequence: | MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVG
PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF
AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL
FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC
KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK
TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL
LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLE
SVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSG
IEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
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| BDBM50333468 |
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| n/a |
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| Name | BDBM50333468 |
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| Synonyms: | 1-(5-tert-butyl-3-((2-(dimethylamino)ethyl)carbamoyl)thiophen-2-yl)-3-(1H-indazol-5-yl)urea | CHEMBL1641790 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H28N6O2S |
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| Mol. Mass. | 428.551 |
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| SMILES | CN(C)CCNC(=O)c1cc(sc1NC(=O)Nc1ccc2[nH]ncc2c1)C(C)(C)C |
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| Structure | 
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