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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sodium-dependent noradrenaline transporter | ||
| Ligand | BDBM50026948 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_700839 (CHEMBL1646233) | ||
| Ki | 44±n/a nM | ||
| Citation |  Banister, SD; Moussa, IA; Beinat, C; Reynolds, AJ; Schiavini, P; Jorgensen, WT; Kassiou, M Trishomocubane as a scaffold for the development of selective dopamine transporter (DAT) ligands. Bioorg Med Chem Lett21:38-41 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sodium-dependent noradrenaline transporter | |||
| Name: | Sodium-dependent noradrenaline transporter | ||
| Synonyms: | Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2 | ||
| Type: | Multi-pass membrane protein | ||
| Mol. Mass.: | 69337.72 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23975 | ||
| Residue: | 617 | ||
| Sequence: |
| ||
| BDBM50026948 | |||
| n/a | |||
| Name | BDBM50026948 | ||
| Synonyms: | (trans) [3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2-ylmethyl]-dimethyl-amine(LR 5182) | CHEMBL173861 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H23Cl2N | ||
| Mol. Mass. | 312.277 | ||
| SMILES | CN(C)C[C@H]1C2CCC(CC2)[C@H]1c1ccc(Cl)c(Cl)c1 |wD:11.13,4.3,(7.55,1.59,;6.22,.82,;4.89,1.59,;6.22,-.68,;4.89,-1.49,;3.54,-.72,;2.22,-1.49,;2.22,-3.03,;3.54,-3.8,;4.09,-2.55,;2.77,-2.03,;4.89,-3.03,;6.2,-3.8,;6.2,-5.34,;7.55,-6.11,;8.89,-5.34,;10.21,-6.11,;8.87,-3.8,;10.2,-2.99,;7.54,-3.03,)| | ||
| Structure | 
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