| Reaction Details |
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 | Report a problem with these data |
| Target | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
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| Ligand | BDBM50335843 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_715335 (CHEMBL1664622) |
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| IC50 | 310±n/a nM |
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| Citation |  Mohamed, HA; Girgis, NM; Wilcken, R; Bauer, MR; Tinsley, HN; Gary, BD; Piazza, GA; Boeckler, FM; Abadi, AH Synthesis and molecular modeling of novel tetrahydro-ß-carboline derivatives with phosphodiesterase 5 inhibitory and anticancer properties. J Med Chem54:495-509 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
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| Name: | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
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| Synonyms: | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | PDE11A | PDE11_HUMAN | Phosphodiesterase 11 | Phosphodiesterase 11A | Phosphodiesterase 11A (PDE11A4) | Phosphodiesterase 11A4 | cAMP and cGMP phosphodiesterase 11A |
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| Type: | Enzyme |
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| Mol. Mass.: | 104751.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9HCR9 |
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| Residue: | 933 |
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| Sequence: | MAASRLDFGEVETFLDRHPELFEDYLMRKGKQEMVEKWLQRHSQGQGALGPRPSLAGTSS
LAHSTCRGGSSVGGGTGPNGSAHSQPLPGGGDCGGVPLSPSWAGGSRGDGNLQRRASQKE
LRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRV
NLPRYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSL
FLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIP
DAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQ
MYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKC
ERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVA
STGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFD
DADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANI
PLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRM
VLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSG
SALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLY
FERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFE
QGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVAT
NRSKWEELHQKRLLASTASSSPASVMVAKEDRN
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| BDBM50335843 |
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| n/a |
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| Name | BDBM50335843 |
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| Synonyms: | (5R,11aR)5-(2,4-Dichlorophenyl)-2-ethyl-5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione | CHEMBL1650673 | CHEMBL1650676 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H17Cl2N3O2 |
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| Mol. Mass. | 414.285 |
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| SMILES | CCn1c(O)c2Cc3c([nH]c4ccccc34)[C@@H](c3ccc(Cl)cc3Cl)n2c1=O |r| |
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| Structure | 
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