| Reaction Details |
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 | Report a problem with these data |
| Target | Type-1 angiotensin II receptor |
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| Ligand | BDBM50049187 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_717480 (CHEMBL1670685) |
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| IC50 | 3.8±n/a nM |
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| Citation |  Naik, P; Murumkar, P; Giridhar, R; Yadav, MR Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective. Bioorg Med Chem18:8418-56 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Type-1 angiotensin II receptor |
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| Name: | Type-1 angiotensin II receptor |
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| Synonyms: | AGTR1 | AGTR1_CAVPO | AT1 | Angiotensin II type-1 receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41004.19 |
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| Organism: | Cavia porcellus |
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| Description: | ChEMBL_36783 |
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| Residue: | 359 |
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| Sequence: | MILNSSTEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADICFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCVIIWLMAGLASLPAVIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFMFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIHDCKISDIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSTLSTKMSTLSYRPSDNVSSSAKKPVQCFEVE
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| BDBM50049187 |
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| n/a |
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| Name | BDBM50049187 |
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| Synonyms: | 5,7-Diethyl-1-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3,4-dihydro-1H-[1,6]naphthyridin-2-one | CHEMBL159096 | ZD-7155 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H26N6O |
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| Mol. Mass. | 438.5242 |
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| SMILES | CCc1cc2N(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)C(=O)CCc2c(CC)n1 |
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| Structure | 
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