| Reaction Details |
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 | Report a problem with these data |
| Target | Squalene synthase |
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| Ligand | BDBM50338903 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_727292 (CHEMBL1687386) |
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| IC50 | 0.45±n/a nM |
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| Citation |  Ichikawa, M; Yokomizo, A; Itoh, M; Sugita, K; Usui, H; Shimizu, H; Suzuki, M; Terayama, K; Kanda, A Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors. Bioorg Med Chem19:1930-49 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Squalene synthase |
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| Name: | Squalene synthase |
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| Synonyms: | FDFT1 | FDFT_HUMAN | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | SQS | SS | Squalene synthetase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48114.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1352847 |
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| Residue: | 417 |
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| Sequence: | MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQA
LDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQ
VLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVG
IGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEVWSRYV
KKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSVFNFCAIPQVMAIATL
AACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVKAIIYQYMEEIYHRIPDSDPSSSKTR
QIISTIRTQNLPNCQLISRSHYSPIYLSFVMLLAALSWQYLTTLSQVTEDYVQTGEH
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| BDBM50338903 |
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| n/a |
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| Name | BDBM50338903 |
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| Synonyms: | CHEMBL1684849 | Ethyl 1-{4-[{4-chloro-2-[(2-fluorophenyl)(hydroxy)-methyl]phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoyl}-piperidine-4-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C30H38ClFN2O5 |
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| Mol. Mass. | 561.085 |
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| SMILES | CCOC(=O)C1CCN(CC1)C(=O)CCC(=O)N(CC(C)(C)C)c1ccc(Cl)cc1C(O)c1ccccc1F |
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| Structure | 
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