Reaction Details |
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Target | Leukotriene A-4 hydrolase |
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Ligand | BDBM50343909 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_747537 (CHEMBL1777071) |
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IC50 | >100000±n/a nM |
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Citation | Chen, Z; Wu, Y; Liu, Y; Yang, S; Chen, Y; Lai, L Discovery of dual target inhibitors against cyclooxygenases and leukotriene A4 hydrolyase. J Med Chem54:3650-60 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Leukotriene A-4 hydrolase |
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Name: | Leukotriene A-4 hydrolase |
Synonyms: | LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase |
Type: | Hydrolase; metalloprotease |
Mol. Mass.: | 69280.41 |
Organism: | Homo sapiens (Human) |
Description: | Human recombinant LTA4H. |
Residue: | 611 |
Sequence: | MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDL
TIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSI
TTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT
AMLVGKDLKVD
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BDBM50343909 |
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n/a |
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Name | BDBM50343909 |
Synonyms: | 1-(2-(4-(4-(Methylsulfonyl)-2-nitrophenoxy)phenoxy)ethyl)pyrrolidine | CHEMBL1775096 |
Type | Small organic molecule |
Emp. Form. | C19H22N2O6S |
Mol. Mass. | 406.453 |
SMILES | CS(=O)(=O)c1ccc(Oc2ccc(OCCN3CCCC3)cc2)c(c1)[N+]([O-])=O |
Structure |
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