| Reaction Details |
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 | Report a problem with these data |
| Target | Indoleamine 2,3-dioxygenase 1 |
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| Ligand | BDBM50347507 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_754733 (CHEMBL1805588) |
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| IC50 | 92000±n/a nM |
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| Citation |  Dolušic, E; Larrieu, P; Blanc, S; Sapunaric, F; Pouyez, J; Moineaux, L; Colette, D; Stroobant, V; Pilotte, L; Colau, D; Ferain, T; Fraser, G; Galleni, M; Frère, JM; Masereel, B; Van den Eynde, B; Wouters, J; Frédérick, R Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors. Eur J Med Chem46:3058-65 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Indoleamine 2,3-dioxygenase 1 |
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| Name: | Indoleamine 2,3-dioxygenase 1 |
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| Synonyms: | I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 45330.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14902 |
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| Residue: | 403 |
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| Sequence: | MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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| BDBM50347507 |
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| n/a |
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| Name | BDBM50347507 |
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| Synonyms: | CHEMBL1802300 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H13FN2O |
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| Mol. Mass. | 268.2856 |
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| SMILES | Cn1c(cc2cc(F)ccc12)C(=O)Cc1cccnc1 |
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| Structure | 
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