| Reaction Details |
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 | Report a problem with these data |
| Target | Transmembrane protease serine 11D |
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| Ligand | BDBM50324475 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_760105 (CHEMBL1810428) |
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| Ki | 19±n/a nM |
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| Citation |  Sielaff, F; Böttcher-Friebertshäuser, E; Meyer, D; Saupe, SM; Volk, IM; Garten, W; Steinmetzer, T Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT. Bioorg Med Chem Lett21:4860-4 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transmembrane protease serine 11D |
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| Name: | Transmembrane protease serine 11D |
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| Synonyms: | Airway trypsin-like protease | HAT | TM11D_HUMAN | TMPRSS11D | Transmembrane protease serine 11D catalytic chain | Transmembrane protease serine 11D non-catalytic chain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 46272.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_840134 |
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| Residue: | 418 |
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| Sequence: | MYRPARVTSTSRFLNPYVVCFIVVAGVVILAVTIALLVYFLAFDQKSYFYRSSFQLLNVE
YNSQLNSPATQEYRTLSGRIESLITKTFKESNLRNQFIRAHVAKLRQDGSGVRADVVMKF
QFTRNNNGASMKSRIESVLRQMLNNSGNLEINPSTEITSLTDQAAANWLINECGAGPDLI
TLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIA
TSGISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQNI
PPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGMLCAGVPQGG
VDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQQTGI
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| BDBM50324475 |
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| n/a |
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| Name | BDBM50324475 |
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| Synonyms: | Benzylsulfonyl-D-argininyl-proline-(4-amidinobenzyl)amide Bis-(trifluoroacetate) | CHEMBL1215083 | CHEMBL1229259 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H36N8O4S |
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| Mol. Mass. | 556.68 |
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| SMILES | NC(=N)NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(cc1)C(N)=N |r| |
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| Structure | 
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