Reaction Details |
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Target | Transient receptor potential cation channel subfamily V member 3 |
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Ligand | BDBM50349984 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_762207 (CHEMBL1816278) |
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IC50 | >10000±n/a nM |
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Citation | Bregman, H; Berry, L; Buchanan, JL; Chen, A; Du, B; Feric, E; Hierl, M; Huang, L; Immke, D; Janosky, B; Johnson, D; Li, X; Ligutti, J; Liu, D; Malmberg, A; Matson, D; McDermott, J; Miu, P; Nguyen, HN; Patel, VF; Waldon, D; Wilenkin, B; Zheng, XM; Zou, A; McDonough, SI; DiMauro, EF Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain. J Med Chem54:4427-45 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Transient receptor potential cation channel subfamily V member 3 |
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Name: | Transient receptor potential cation channel subfamily V member 3 |
Synonyms: | TRPV3 | TRPV3_HUMAN | Transient receptor potential cation channel subfamily V member 3 (TRPV3) | Vanilloid receptor-like 3 |
Type: | Enzyme |
Mol. Mass.: | 90635.51 |
Organism: | Homo sapiens (Human) |
Description: | Q8NET8 |
Residue: | 790 |
Sequence: | MKAHPKEMVPLMGKRVAAPSGNPAILPEKRPAEITPTKKSAHFFLEIEGFEPNPTVAKTS
PPVFSKPMDSNIRQCISGNCDDMDSPQSPQDDVTETPSNPNSPSAQLAKEEQRRKKRRLK
KRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNIN
PNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGAD
VNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNIL
HALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYI
LSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEML
TLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMG
WLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLY
LFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLG
FGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLIT
YVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGEL
CKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTDFNKIQDSSRNNSKTTLNAFE
EVEEFPETSV
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BDBM50349984 |
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n/a |
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Name | BDBM50349984 |
Synonyms: | CHEMBL1813048 |
Type | Small organic molecule |
Emp. Form. | C25H27F3N6O3 |
Mol. Mass. | 516.5155 |
SMILES | CC(=O)Nc1cccc(Nc2ncnc(n2)N2CCC(CC2)OCc2ccc(OC(F)(F)F)cc2)c1C |
Structure |
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