| Reaction Details |
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 | Report a problem with these data |
| Target | NAD-dependent protein deacetylase sirtuin-2 |
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| Ligand | BDBM50350509 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_762656 (CHEMBL1817380) |
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| IC50 | 159100±n/a nM |
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| Citation |  Hirsch, BM; Hao, Y; Li, X; Wesdemiotis, C; Wang, Z; Zheng, W A mechanism-based potent sirtuin inhibitor containing Ne-thiocarbamoyl-lysine (TuAcK). Bioorg Med Chem Lett21:4753-7 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NAD-dependent protein deacetylase sirtuin-2 |
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| Name: | NAD-dependent protein deacetylase sirtuin-2 |
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| Synonyms: | NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2) |
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| Type: | Hydrolase |
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| Mol. Mass.: | 43172.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 389 |
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| Sequence: | MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLD
ELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFE
ISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQ
EDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLP
ARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMI
MGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGV
PNPSTSASPKKSPPPAKDEARTTEREKPQ
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| BDBM50350509 |
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| n/a |
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| Name | BDBM50350509 |
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| Synonyms: | CHEMBL1814814 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H42N8O6S |
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| Mol. Mass. | 558.695 |
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| SMILES | CC(=O)NCCC[C@H](NC(=O)[C@H](CCCCNC(N)=S)NC(=O)[C@H](CCCNC(C)=O)NC(C)=O)C(N)=O |r| |
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| Structure | 
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