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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bile acid receptor | ||
| Ligand | BDBM50355024 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_772464 (CHEMBL1839255) | ||
| EC50 | 670±n/a nM | ||
| Citation |  Akwabi-Ameyaw, A; Caravella, JA; Chen, L; Creech, KL; Deaton, DN; Madauss, KP; Marr, HB; Miller, AB; Navas, F; Parks, DJ; Spearing, PK; Todd, D; Williams, SP; Wisely, GB Conformationally constrained farnesoid X receptor (FXR) agonists: alternative replacements of the stilbene. Bioorg Med Chem Lett21:6154-60 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bile acid receptor | |||
| Name: | Bile acid receptor | ||
| Synonyms: | BAR | Bile acid receptor FXR | FXR | Farnesol receptor HRR-1 | HRR1 | NR1H4 | NR1H4_HUMAN | Nuclear receptor subfamily 1 group H member 4 | RIP14 | RXR-interacting protein 14 | Retinoid X receptor-interacting protein 14 | farnesoid x receptor | ||
| Type: | Nuclear Receptor | ||
| Mol. Mass.: | 55916.24 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q96RI1 | ||
| Residue: | 486 | ||
| Sequence: |
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| BDBM50355024 | |||
| n/a | |||
| Name | BDBM50355024 | ||
| Synonyms: | CHEMBL1835050 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H20Cl2N2O4S | ||
| Mol. Mass. | 539.43 | ||
| SMILES | CC(C)c1onc(c1COc1ccc(cc1)-c1ccc2sc(cc2n1)C(O)=O)-c1c(Cl)cccc1Cl |(25.45,-37.97,;25.13,-39.48,;23.67,-39.96,;26.28,-40.51,;27.79,-40.18,;28.56,-41.51,;27.54,-42.66,;26.13,-42.04,;24.8,-42.82,;23.46,-42.05,;22.13,-42.83,;22.13,-44.38,;20.8,-45.15,;19.46,-44.38,;19.47,-42.83,;20.79,-42.06,;18.13,-45.14,;18.09,-46.68,;16.73,-47.41,;15.43,-46.61,;13.96,-47.06,;13.08,-45.79,;14.01,-44.57,;15.46,-45.08,;16.82,-44.34,;11.54,-45.76,;10.8,-44.41,;10.74,-47.08,;27.86,-44.16,;29.32,-44.62,;30.46,-43.58,;29.65,-46.12,;28.51,-47.17,;27.04,-46.7,;26.72,-45.19,;25.25,-44.72,)| | ||
| Structure | 
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