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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bile acid receptor | ||
| Ligand | BDBM50355018 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_772465 (CHEMBL1839256) | ||
| EC50 | 500±n/a nM | ||
| Citation |  Akwabi-Ameyaw, A; Caravella, JA; Chen, L; Creech, KL; Deaton, DN; Madauss, KP; Marr, HB; Miller, AB; Navas, F; Parks, DJ; Spearing, PK; Todd, D; Williams, SP; Wisely, GB Conformationally constrained farnesoid X receptor (FXR) agonists: alternative replacements of the stilbene. Bioorg Med Chem Lett21:6154-60 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bile acid receptor | |||
| Name: | Bile acid receptor | ||
| Synonyms: | BAR | Bile acid receptor FXR | FXR | Farnesol receptor HRR-1 | HRR1 | NR1H4 | NR1H4_HUMAN | Nuclear receptor subfamily 1 group H member 4 | RIP14 | RXR-interacting protein 14 | Retinoid X receptor-interacting protein 14 | farnesoid x receptor | ||
| Type: | Nuclear Receptor | ||
| Mol. Mass.: | 55916.24 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q96RI1 | ||
| Residue: | 486 | ||
| Sequence: |
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| BDBM50355018 | |||
| n/a | |||
| Name | BDBM50355018 | ||
| Synonyms: | CHEMBL1835045 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H24Cl2N2O4 | ||
| Mol. Mass. | 535.418 | ||
| SMILES | CC(C)c1onc(c1COc1ccc(Cn2ccc3ccc(cc23)C(O)=O)cc1)-c1c(Cl)cccc1Cl |(15.55,-27.25,;15.53,-28.79,;14.18,-29.54,;16.85,-29.58,;18.31,-29.08,;19.23,-30.3,;18.35,-31.57,;16.88,-31.12,;15.55,-31.9,;14.21,-31.13,;12.88,-31.91,;11.55,-31.14,;10.22,-31.91,;10.22,-33.46,;8.88,-34.23,;7.64,-33.32,;7.64,-31.78,;6.18,-31.3,;5.28,-32.54,;3.75,-32.7,;3.12,-34.09,;4.02,-35.34,;5.54,-35.18,;6.17,-33.79,;3.39,-36.75,;4.3,-38,;1.86,-36.91,;11.55,-34.23,;12.89,-33.46,;19.09,-32.92,;20.63,-32.94,;21.42,-31.62,;21.37,-34.28,;20.57,-35.61,;19.03,-35.58,;18.29,-34.23,;16.75,-34.19,)| | ||
| Structure | 
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