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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bile acid receptor | ||
| Ligand | BDBM50355020 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_772465 (CHEMBL1839256) | ||
| EC50 | 990±n/a nM | ||
| Citation |  Akwabi-Ameyaw, A; Caravella, JA; Chen, L; Creech, KL; Deaton, DN; Madauss, KP; Marr, HB; Miller, AB; Navas, F; Parks, DJ; Spearing, PK; Todd, D; Williams, SP; Wisely, GB Conformationally constrained farnesoid X receptor (FXR) agonists: alternative replacements of the stilbene. Bioorg Med Chem Lett21:6154-60 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bile acid receptor | |||
| Name: | Bile acid receptor | ||
| Synonyms: | BAR | Bile acid receptor FXR | FXR | Farnesol receptor HRR-1 | HRR1 | NR1H4 | NR1H4_HUMAN | Nuclear receptor subfamily 1 group H member 4 | RIP14 | RXR-interacting protein 14 | Retinoid X receptor-interacting protein 14 | farnesoid x receptor | ||
| Type: | Nuclear Receptor | ||
| Mol. Mass.: | 55916.24 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q96RI1 | ||
| Residue: | 486 | ||
| Sequence: |
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| BDBM50355020 | |||
| n/a | |||
| Name | BDBM50355020 | ||
| Synonyms: | CHEMBL1835046 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H21Cl2NO4S2 | ||
| Mol. Mass. | 570.507 | ||
| SMILES | CC(C)c1onc(c1COc1ccc(Sc2cccc3sc(cc23)C(O)=O)cc1)-c1c(Cl)cccc1Cl |(46.86,-16.34,;46.54,-17.84,;45.08,-18.32,;47.69,-18.87,;49.2,-18.54,;49.97,-19.87,;48.95,-21.02,;47.54,-20.4,;46.21,-21.18,;44.87,-20.41,;43.54,-21.19,;43.55,-22.74,;42.21,-23.51,;40.88,-22.74,;39.54,-23.51,;38.21,-22.74,;38.22,-21.2,;36.89,-20.43,;35.55,-21.2,;35.55,-22.74,;34.42,-23.78,;35.05,-25.17,;36.57,-25.01,;36.89,-23.51,;34.28,-26.52,;32.74,-26.52,;35.06,-27.85,;40.88,-21.19,;42.21,-20.42,;49.27,-22.53,;50.73,-22.99,;51.87,-21.95,;51.07,-24.49,;49.92,-25.53,;48.45,-25.06,;48.13,-23.56,;46.66,-23.08,)| | ||
| Structure | 
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