Reaction Details |
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Target | Renin |
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Ligand | BDBM50355538 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_776557 (CHEMBL1913654) |
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IC50 | 0.18±n/a nM |
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Citation | Chen, A; Cauchon, E; Chefson, A; Dolman, S; Ducharme, Y; Dubé, D; Falgueyret, JP; Fournier, PA; Gagné, S; Gallant, M; Grimm, E; Han, Y; Houle, R; Huang, JQ; Hughes, G; Jûteau, H; Lacombe, P; Lauzon, S; Lévesque, JF; Liu, S; Macdonald, D; Mackay, B; McKay, D; Percival, MD; St-Jacques, R; Toulmond, S Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of tertiary alcohol-bearing piperidines. Bioorg Med Chem Lett21:3976-81 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Renin |
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Name: | Renin |
Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 45058.99 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 406 |
Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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BDBM50355538 |
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n/a |
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Name | BDBM50355538 |
Synonyms: | CHEMBL1910304 |
Type | Small organic molecule |
Emp. Form. | C30H36F3N3O5S |
Mol. Mass. | 607.684 |
SMILES | COCCCn1cc(CN(C2CC2)C(=O)[C@H]2CNCC[C@]2(O)c2ccc(F)c(F)c2)c2c(F)ccc(CS(C)(=O)=O)c12 |r| |
Structure |
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