Reaction Details | |||
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Target | Neuronal acetylcholine receptor subunit alpha-7 | ||
Ligand | BDBM50356467 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_775797 (CHEMBL1912300) | ||
Ki | 42±n/a nM | ||
Citation | Kombo, DC; Mazurov, A; Tallapragada, K; Hammond, PS; Chewning, J; Hauser, TA; Vasquez-Valdivieso, M; Yohannes, D; Talley, TT; Taylor, P; Caldwell, WS Docking studies of benzylidene anabaseine interactions witha7 nicotinic acetylcholine receptor (nAChR) and acetylcholine binding proteins (AChBPs): application to the design of relateda7 selective ligands. Eur J Med Chem46:5625-35 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Neuronal acetylcholine receptor subunit alpha-7 | |||
Name: | Neuronal acetylcholine receptor subunit alpha-7 | ||
Synonyms: | ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR) | ||
Type: | Enzyme | ||
Mol. Mass.: | 56502.44 | ||
Organism: | Rattus norvegicus (Rat) | ||
Description: | Q05941 | ||
Residue: | 502 | ||
Sequence: |
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BDBM50356467 | |||
n/a | |||
Name | BDBM50356467 | ||
Synonyms: | CHEMBL1911855 | ||
Type | Small organic molecule | ||
Emp. Form. | C18H23N3O2 | ||
Mol. Mass. | 313.3941 | ||
SMILES | COc1ccc(cc1)C1=NCC2(CN3CCC2CC3)NC(=O)C1 |t:9,(6.56,-10.44,;5.77,-11.76,;4.24,-11.74,;3.45,-13.07,;1.91,-13.04,;1.16,-11.69,;1.95,-10.38,;3.48,-10.39,;-.37,-11.67,;-1.06,-13.06,;-2.57,-13.38,;-3.77,-12.4,;-3.77,-13.94,;-5.1,-14.7,;-6.42,-13.94,;-6.42,-12.4,;-5.1,-11.62,;-4.34,-12.95,;-5.68,-13.71,;-3.74,-10.86,;-2.51,-9.91,;-2.84,-8.4,;-1.01,-10.27,)| | ||
Structure |