Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Thymidylate kinase |
---|
Ligand | BDBM50314850 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_793312 (CHEMBL1931815) |
---|
Ki | 9900±n/a nM |
---|
Citation | Van Poecke, S; Munier-Lehmann, H; Helynck, O; Froeyen, M; Van Calenbergh, S Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase. Bioorg Med Chem19:7603-11 (2011) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Thymidylate kinase |
---|
Name: | Thymidylate kinase |
Synonyms: | KTHY_MYCTU | TMPK | Thymidine monophosphate kinase | dTMP kinase | tmk |
Type: | PROTEIN |
Mol. Mass.: | 22636.29 |
Organism: | Mycobacterium tuberculosis |
Description: | ChEMBL_208218 |
Residue: | 214 |
Sequence: | MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAADIAAEALHGEHGDLA
SSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVASNAAYSAARLHENAAGKAAAWV
QRIEFARLGLPKPDWQVLLAVSAELAGERSRGRAQRDPGRARDNYERDAELQQRTGAVYA
ELAAQGWGGRWLVVGADVDPGRLAATLAPPDVPS
|
|
|
BDBM50314850 |
---|
n/a |
---|
Name | BDBM50314850 |
Synonyms: | 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-((2S,3S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)thiourea | CHEMBL1091873 |
Type | Small organic molecule |
Emp. Form. | C18H18ClF3N4O4S |
Mol. Mass. | 478.873 |
SMILES | Cc1cn([C@H]2C[C@H](NC(=S)Nc3ccc(Cl)c(c3)C(F)(F)F)[C@@H](CO)O2)c(=O)[nH]c1=O |r| |
Structure |
|