| Reaction Details |
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 | Report a problem with these data |
| Target | Natural resistance-associated macrophage protein 2 |
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| Ligand | BDBM54072 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_795244 (CHEMBL1936903) |
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| IC50 | 2570±n/a nM |
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| Citation |  Cadieux, JA; Zhang, Z; Mattice, M; Brownlie-Cutts, A; Fu, J; Ratkay, LG; Kwan, R; Thompson, J; Sanghara, J; Zhong, J; Goldberg, YP Synthesis and biological evaluation of substituted pyrazoles as blockers of divalent metal transporter 1 (DMT1). Bioorg Med Chem Lett22:90-5 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Natural resistance-associated macrophage protein 2 |
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| Name: | Natural resistance-associated macrophage protein 2 |
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| Synonyms: | DCT1 | DMT-1 | DMT1 | Divalent cation transporter 1 | Divalent metal transporter 1 | NRAM2_HUMAN | NRAMP 2 | NRAMP2 | SLC11A2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 62262.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_795244 |
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| Residue: | 568 |
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| Sequence: | MVLGPEQKMSDDSVSGDHGESASLGNINPAYSNPSLSQSPGDSEEYFATYFNEKISIPEE
EYSCFSFRKLWAFTGPGFLMSIAYLDPGNIESDLQSGAVAGFKLLWILLLATLVGLLLQR
LAARLGVVTGLHLAEVCHRQYPKVPRVILWLMVELAIIGSDMQEVIGSAIAINLLSVGRI
PLWGGVLITIADTFVFLFLDKYGLRKLEAFFGFLITIMALTFGYEYVTVKPSQSQVLKGM
FVPSCSGCRTPQIEQAVGIVGAVIMPHNMYLHSALVKSRQVNRNNKQEVREANKYFFIES
CIALFVSFIINVFVVSVFAEAFFGKTNEQVVEVCTNTSSPHAGLFPKDNSTLAVDIYKGG
VVLGCYFGPAALYIWAVGILAAGQSSTMTGTYSGQFVMEGFLNLKWSRFARVVLTRSIAI
IPTLLVAVFQDVEHLTGMNDFLNVLQSLQLPFALIPILTFTSLRPVMSDFANGLGWRIAG
GILVLIICSINMYFVVVYVRDLGHVALYVVAAVVSVAYLGFVFYLGWQCLIALGMSFLDC
GHTCHLGLTAQPELYLLNTMDADSLVSR
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| BDBM54072 |
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| n/a |
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| Name | BDBM54072 |
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| Synonyms: | 3-[(4Z)-4-[4-(diethylamino)benzylidene]-5-keto-3-methyl-2-pyrazolin-1-yl]-6-methyl-2H-1,2,4-triazin-5-one | 3-[(4Z)-4-[[4-(diethylamino)phenyl]methylidene]-3-methyl-5-oxidanylidene-pyrazol-1-yl]-6-methyl-2H-1,2,4-triazin-5-one | 3-[(4Z)-4-[[4-(diethylamino)phenyl]methylidene]-3-methyl-5-oxo-1-pyrazolyl]-6-methyl-2H-1,2,4-triazin-5-one | 3-[(4Z)-4-[[4-(diethylamino)phenyl]methylidene]-3-methyl-5-oxopyrazol-1-yl]-6-methyl-2H-1,2,4-triazin-5-one | 3-{4-[1-(4-Diethylamino-phenyl)-meth-(Z)-ylidene]-3-methyl-5-oxo-4,5-dihydro-pyrazol-1-yl}-6-methyl-4H -[1,2,4]triazin-5-one | CHEMBL1548704 | MLS000777021 | SMR000413411 | cid_5710537 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H22N6O2 |
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| Mol. Mass. | 366.417 |
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| SMILES | CCN(CC)c1ccc(C=c2c(=C)[nH]n(-c3nnc(C)c(=O)[nH]3)c2=O)cc1 |w:9.8| |
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| Structure | 
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