| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Endothelin-1 receptor |
|---|
| Ligand | BDBM50070881 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_63346 |
|---|
| IC50 | 1.4±n/a nM |
|---|
| Citation |  Mederski, WW; Dorsch, D; Osswald, M; Anzali, S; Christadler, M; Schmitges, CJ; Schelling, P; Wilm, C; Fluck, M Endothelin antagonists: discovery of EMD 122946, a highly potent and orally active ETA selective antagonist. Bioorg Med Chem Lett8:1771-6 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Endothelin-1 receptor |
|---|
| Name: | Endothelin-1 receptor |
|---|
| Synonyms: | EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 48256.91 |
|---|
| Organism: | RAT |
|---|
| Description: | ENDOTHELIN A EDNRA RAT::P26684 |
|---|
| Residue: | 426 |
|---|
| Sequence: | MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALP
SNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCM
LNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSS
HKDSMN
|
|
|
|---|
| BDBM50070881 |
|---|
| n/a |
|---|
| Name | BDBM50070881 |
|---|
| Synonyms: | CHEMBL295483 | Sodium; (Z)-2-benzo[1,2,5]thiadiazol-5-yl-4-(4-methoxy-3-methyl-phenyl)-4-oxo-3-(3,4,5-trimethoxy-benzyl)-but-2-enoate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H25N2O7S |
|---|
| Mol. Mass. | 533.573 |
|---|
| SMILES | COc1ccc(cc1C)C(=O)C(\Cc1cc(OC)c(OC)c(OC)c1)=C(/C([O-])=O)c1ccc2nsnc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
