| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin receptor type B |
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| Ligand | BDBM50070883 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_63877 |
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| IC50 | 290±n/a nM |
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| Citation |  Mederski, WW; Dorsch, D; Osswald, M; Anzali, S; Christadler, M; Schmitges, CJ; Schelling, P; Wilm, C; Fluck, M Endothelin antagonists: discovery of EMD 122946, a highly potent and orally active ETA selective antagonist. Bioorg Med Chem Lett8:1771-6 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin receptor type B |
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| Name: | Endothelin receptor type B |
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| Synonyms: | EDNRB | EDNRB_PIG | Endothelin receptor ET-B |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49616.89 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_63872 |
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| Residue: | 443 |
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| Sequence: | MQPLRSLCGRALVALIFACGVAGVQSEERGFPPAGATPPALRTGEIVAPPTKTFWPRGSN
ASLPRSSSPPQMPKGGRMAGPPARTLTPPPCEGPIEIKDTFKYINTVVSCLVFVLGIIGN
STLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPF
IQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEALG
FDMITTDYKGNRLRICLLHPTQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCE
MLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQNDSNRCE
LLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQS
CLKFKANDHGYDNFRSSNKYSSS
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| BDBM50070883 |
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| n/a |
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| Name | BDBM50070883 |
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| Synonyms: | CHEMBL300201 | Sodium; (Z)-2-benzo[1,2,5]thiadiazol-5-yl-4-(3-fluoro-4-isopropoxy-phenyl)-4-oxo-3-(3,4,5-trimethoxy-benzyl)-but-2-enoate |
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| Type | Small organic molecule |
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| Emp. Form. | C29H26FN2O7S |
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| Mol. Mass. | 565.59 |
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| SMILES | COc1cc(C\C(C(=O)c2ccc(OC(C)C)c(F)c2)=C(\C([O-])=O)c2ccc3nsnc3c2)cc(OC)c1OC |
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| Structure | 
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