Reaction Details |
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Target | Endothelin-1 receptor |
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Ligand | BDBM50070872 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_63346 |
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IC50 | 57±n/a nM |
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Citation | Mederski, WW; Dorsch, D; Osswald, M; Anzali, S; Christadler, M; Schmitges, CJ; Schelling, P; Wilm, C; Fluck, M Endothelin antagonists: discovery of EMD 122946, a highly potent and orally active ETA selective antagonist. Bioorg Med Chem Lett8:1771-6 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Endothelin-1 receptor |
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Name: | Endothelin-1 receptor |
Synonyms: | EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 48256.91 |
Organism: | RAT |
Description: | ENDOTHELIN A EDNRA RAT::P26684 |
Residue: | 426 |
Sequence: | MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALP
SNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCM
LNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSS
HKDSMN
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BDBM50070872 |
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n/a |
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Name | BDBM50070872 |
Synonyms: | CHEMBL276362 | Sodium; (Z)-2-benzo[1,2,5]thiadiazol-5-yl-4-(4-methoxy-phenyl)-4-oxo-3-(3,4,5-triisopropoxy-benzyl)-but-2-enoate |
Type | Small organic molecule |
Emp. Form. | C33H35N2O7S |
Mol. Mass. | 603.706 |
SMILES | COc1ccc(cc1)C(=O)C(\Cc1cc(OC(C)C)c(OC(C)C)c(OC(C)C)c1)=C(/C([O-])=O)c1ccc2nsnc2c1 |
Structure |
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