| Reaction Details |
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 | Report a problem with these data |
| Target | Collagenase 3 |
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| Ligand | BDBM50071837 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_106628 |
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| IC50 | 6.2±n/a nM |
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| Citation |  Levin, JI; DiJoseph, JF; Killar, LM; Sung, A; Walter, T; Sharr, MA; Roth, CE; Skotnicki, JS; Albright, JD The synthesis and biological activity of a novel series of diazepine MMP inhibitors. Bioorg Med Chem Lett8:2657-62 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Collagenase 3 |
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| Name: | Collagenase 3 |
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| Synonyms: | MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13) |
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| Type: | Enzyme |
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| Mol. Mass.: | 53808.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P45452 |
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| Residue: | 471 |
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| Sequence: | MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA
ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG
PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET
MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY
DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI
EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
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| BDBM50071837 |
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| n/a |
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| Name | BDBM50071837 |
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| Synonyms: | 1-(4-Methoxy-benzenesulfonyl)-4-(4-trifluoromethoxy-benzoyl)-[1,4]diazepane-2-carboxylic acid hydroxyamide | CHEMBL329558 | N-hydroxy-1-(4-methoxyphenylsulfonyl)-4-(4-(trifluoromethoxy)benzoyl)-1,4-diazepane-2-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22F3N3O7S |
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| Mol. Mass. | 517.475 |
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| SMILES | COc1ccc(cc1)S(=O)(=O)N1CCCN(CC1C(=O)NO)C(=O)c1ccc(OC(F)(F)F)cc1 |
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| Structure | 
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