| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingomyelin phosphodiesterase 2 |
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| Ligand | BDBM50128896 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_144315 |
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| IC50 | 8700±n/a nM |
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| Citation |  Taguchi, M; Sugimoto, K; Goda, K; Akama, T; Yamamoto, K; Suzuki, T; Tomishima, Y; Nishiguchi, M; Arai, K; Takahashi, K; Kobori, T Sphingomyelin analogues as inhibitors of sphingomyelinase. Bioorg Med Chem Lett13:1963-6 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingomyelin phosphodiesterase 2 |
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| Name: | Sphingomyelin phosphodiesterase 2 |
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| Synonyms: | NSMA_RAT | Neutral sphingomyelinase | Smpd2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47651.22 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_611790 |
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| Residue: | 422 |
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| Sequence: | MKHNFSLRLRVFNLNCWDIPYLSKHRADRMKRLGDFLNLESFDLALLEEVWSEQDFQYLK
QKLSLTYPDAHYFRSGIIGSGLCVFSRHPIQEIVQHVYTLNGYPYKFYHGDWFCGKAVGL
LVLHLSGLVLNAYVTHLHAEYSRQKDIYFAHRVAQAWELAQFIHHTSKKANVVLLCGDLN
MHPKDLGCCLLKEWTGLRDAFVETEDFKGSEDGCTMVPKNCYVSQQDLGPFPFGVRIDYV
LYKAVSGFHICCKTLKTTTGCDPHNGTPFSDHEALMATLCVKHSPPQEDPCSAHGSAERS
ALISALREARTELGRGIAQARWWAALFGYVMILGLSLLVLLCVLAAGEEAREVAIMLWTP
SVGLVLGAGAVYLFHKQEAKSLCRAQAEIQHVLTRTTETQDLGSEPHPTHCRQQEADRAE
EK
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| BDBM50128896 |
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| n/a |
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| Name | BDBM50128896 |
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| Synonyms: | CHEMBL416323 | {2-[(E)-(2S,3R)-2-(2,2-Dimethyl-propionylamino)-3-hydroxy-octadec-4-enyloxycarbonylamino]-ethyl}-trimethyl-ammonium; iodide |
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| Type | Small organic molecule |
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| Emp. Form. | C29H58N3O4 |
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| Mol. Mass. | 512.788 |
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| SMILES | CCCCCCCCCCCCC\C=C\[C@@H](O)[C@H](COC(=O)NCC[N+](C)(C)C)NC(=O)C(C)(C)C |
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| Structure | 
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