| Reaction Details |
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 | Report a problem with these data |
| Target | Phenylethanolamine N-methyltransferase |
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| Ligand | BDBM50028908 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_152573 |
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| IC50 | 100±n/a nM |
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| Citation |  DeMarinis, RM; Bryan, WM; Hillegass, LM; McDermott, D; Pendleton, RG Inhibitors of phenylethanolamine N-methyltransferase and epinephrine biosynthesis. 3. Bis[tetrahydroisoquinoline]s. J Med Chem24:756-9 (1981) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Phenylethanolamine N-methyltransferase |
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| Name: | Phenylethanolamine N-methyltransferase |
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| Synonyms: | Noradrenaline N-methyltransferase | PENT | PNMT | PNMT_HUMAN | PNMTase | Phenylethanolamine N-Methyltransferase (PNMT) |
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| Type: | Enzyme |
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| Mol. Mass.: | 30852.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 282 |
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| Sequence: | MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGA
FNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVR
EALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
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| BDBM50028908 |
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| n/a |
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| Name | BDBM50028908 |
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| Synonyms: | 7,8-dichloro-2-[4-(7,8-dichloro-1,2,3,4-tetrahydro-2-isoquinolinyl)butyl]-1,2,3,4-tetrahydroisoquinoline; dihydrochloride | CHEMBL556970 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24Cl4N2 |
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| Mol. Mass. | 458.251 |
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| SMILES | Clc1ccc2CCN(CCCCN3CCc4ccc(Cl)c(Cl)c4C3)Cc2c1Cl |
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| Structure | 
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