Reaction Details |
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Target | Thromboxane-A synthase |
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Ligand | BDBM50024113 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_210451 (CHEMBL814403) |
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IC50 | 6000±n/a nM |
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Citation | Press, JB; Wright, WB; Chan, PS; Marsico, JW; Haug, MF; Tauber, J; Tomcufcik, AS Thromboxane synthetase inhibitors and antihypertensive agents. 2. N-[(1H-imidazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones and N-[(1H-1,2,4-triazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones as unique antihypertensive agents. J Med Chem29:816-9 (1986) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Thromboxane-A synthase |
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Name: | Thromboxane-A synthase |
Synonyms: | Cyp5 | Cyp5a1 | Cytochrome P450 5A1 | THAS_RAT | TXA synthase | TXS | Tbxas1 |
Type: | PROTEIN |
Mol. Mass.: | 59971.80 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_209768 |
Residue: | 533 |
Sequence: | MEVLGLLKFEVSGTVVTVTLSVVLLALLKWYSTSAFSRLRKLGIRHPEPSPFVGNLMFFR
QGFWESHLELRERYGPLCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNRMASGLEPKLI
ADSVLMLRDRRWEEVRGALMSAFSPEKLNEMTPLISQACELLLSHLKHSAASGDAFDIQR
CYCCFTTNVVASVAFGIEVNSQDAPEDPFVQHCQRVFAFSTPRPLLALILSFPSIMVPLA
RILPNKNRDELNGFFNTLIRNVIALRDKQTAEERRGDFLQMVLDAQRSMSSVGVEAFDMV
TEALSSAECMGDPPQRCHPTSTAKPLTVDEIAGQAFLFLIAGHEITTNTLSFITYLLATH
PECQERLLKEVDLFMEKHPAPEYCNLQEGLPYLDMVVAETLRMYPPAFRFTREAAQDCEV
LGQHIPAGSVLEIAVGALHHDPEHWPNPETFDPERFTAEARLQQKPFTYLPFGAGPRSCL
GVRLGLLVVKLTLLQVLHKFRFEACPETQVPLQLESKSALCPKNGVYVKIVSR
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BDBM50024113 |
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n/a |
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Name | BDBM50024113 |
Synonyms: | 2-(5-Imidazol-1-yl-pentyl)-isoindole-1,3-dione; hydrochloride | CHEMBL558783 |
Type | Small organic molecule |
Emp. Form. | C16H17N3O2 |
Mol. Mass. | 283.3251 |
SMILES | O=C1N(CCCCCn2ccnc2)C(=O)c2ccccc12 |
Structure |
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