| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1A |
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| Ligand | BDBM50017432 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1176 (CHEMBL615942) |
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| Ki | 10±n/a nM |
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| Citation |  Abou-Gharbia, M; Moyer, JA; Patel, U; Webb, M; Schiehser, G; Andree, T; Haskins, JT Synthesis and structure-activity relationship of substituted tetrahydro- and hexahydro-1,2-benzisothiazol-3-one 1,1-dioxides and thiadiazinones: potential anxiolytic agents. J Med Chem32:1024-33 (1989) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 1A |
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| Name: | 5-hydroxytryptamine receptor 1A |
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| Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46445.29 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Binding assays were performed using rat hippocampal membranes. |
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| Residue: | 422 |
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| Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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| BDBM50017432 |
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| n/a |
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| Name | BDBM50017432 |
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| Synonyms: | 4-{4-[4-(2-pyrimidinyl)hexahydro-1-pyrazinyl]butyl}-5-sulfo-4-azatetracyclo[5.4.2.02,6.08,11]trideca-9,12-dien-3-one; diHydrochloride | CHEMBL3216636 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H31Cl2N5O3S |
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| Mol. Mass. | 528.495 |
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| SMILES | Cl.Cl.O=C1C2C(C3C=CC2C2C=CC32)S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1 |c:5,10,TLB:14:5:10.13:8.7,THB:12:13:4.5:8.7,11:10:4.5:8.7| |
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| Structure | 
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