Reaction Details |
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Target | Potassium-transporting ATPase alpha chain 1/subunit beta |
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Ligand | BDBM50013297 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_75907 (CHEMBL686427) |
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IC50 | 25000±n/a nM |
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Citation | LaMattina, JL; McCarthy, PA; Reiter, LA; Holt, WF; Yeh, LA Antiulcer agents. 4-substituted 2-guanidinothiazoles: reversible, competitive, and selective inhibitors of gastric H+,K(+)-ATPase. J Med Chem33:543-52 (1990) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Potassium-transporting ATPase alpha chain 1/subunit beta |
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Name: | Potassium-transporting ATPase alpha chain 1/subunit beta |
Synonyms: | Potassium-transporting ATPase | Potassium-transporting ATPase alpha chain 1/beta chain |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of EBI is 71495 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Potassium-transporting ATPase alpha chain 1 |
Synonyms: | ATP4A | ATP4A_HUMAN | Gastric H(+)/K(+) ATPase subunit alpha | Potassium-transporting ATPase | Potassium-transporting ATPase alpha chain 1 | Proton pump |
Type: | PROTEIN |
Mol. Mass.: | 114109.05 |
Organism: | Homo sapiens (Human) |
Description: | EBI_82 |
Residue: | 1035 |
Sequence: | MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVA
ELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAA
ICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQA
TVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSP
ECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIE
HFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAK
RLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQ
TFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMG
YRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELP
LDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLV
SMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLR
VPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLG
AIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIF
DNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAES
DIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQ
WEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGF
FRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLG
VRCCPGSWWDQELYY
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Component 2 |
Name: | Potassium-transporting ATPase subunit beta |
Synonyms: | ATP4B | ATP4B_HUMAN | Gastric H(+)/K(+) ATPase subunit beta | Potassium-transporting ATPase | Potassium-transporting ATPase subunit beta | Proton pump beta chain |
Type: | PROTEIN |
Mol. Mass.: | 33369.83 |
Organism: | Homo sapiens (Human) |
Description: | EBI_10719 |
Residue: | 291 |
Sequence: | MAALQEKKTCGQRMEEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALCLY
VLMQTVDPYTPDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLAGY
SPAAQEDSINCTSEQYFFQESFRAPNHTKFSCKFTADMLQNCSGLADPNFGFEEGKPCFI
IKMNRIVKFLPSNGSAPRVDCAFLDQPRELGQPLQVKYYPPNGTFSLHYFPYYGKKAQPH
YSNPLVAAKLLNIPRNAEVAIVCKVMAEHVTFNNPHDPYEGKVEFKLKIEK
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BDBM50013297 |
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n/a |
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Name | BDBM50013297 |
Synonyms: | CHEMBL149689 | N-[4-(5-Methyl-1H-pyrrol-3-yl)-thiazol-2-yl]-guanidine |
Type | Small organic molecule |
Emp. Form. | C9H11N5S |
Mol. Mass. | 221.282 |
SMILES | Cc1cc(c[nH]1)-c1csc(N=C(N)N)n1 |(18.9,-14.7,;17.37,-14.88,;16.59,-16.21,;15.08,-15.91,;14.92,-14.38,;16.33,-13.73,;13.86,-16.84,;13.89,-18.36,;12.45,-18.88,;11.52,-17.64,;9.97,-17.68,;9.23,-19.03,;7.69,-19.06,;10.04,-20.34,;12.41,-16.39,)| |
Structure |
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