| Reaction Details |
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 | Report a problem with these data |
| Target | Gastrin/cholecystokinin type B receptor |
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| Ligand | BDBM50008175 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_48430 |
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| IC50 | 800±n/a nM |
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| Citation |  Makovec, F; Peris, W; Revel, L; Giovanetti, R; Mennuni, L; Rovati, LC Structure-antigastrin activity relationships of new (R)-4-benzamido-5-oxopentanoic acid derivatives. J Med Chem35:28-38 (1992) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Gastrin/cholecystokinin type B receptor |
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| Name: | Gastrin/cholecystokinin type B receptor |
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| Synonyms: | CCK-2 receptor | CCK-B receptor | CCK-BR | CCKBR | CCKRB | Cholecystokinin A | Cholecystokinin receptor | Cholecystokinin-2 Receptor | GASR_HUMAN | Gastrin/cholecystokinin type B receptor |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48445.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Stable expression of human CCK-2 receptors in HEK 293 cells. |
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| Residue: | 447 |
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| Sequence: | MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITL
YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWL
LSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGL
ISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRS
RPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDG
PGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRAL
PDEDPPTPSIASLSRLSYTTISTLGPG
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| BDBM50008175 |
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| n/a |
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| Name | BDBM50008175 |
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| Synonyms: | 4-(8-Aza-spiro[4.5]dec-8-ylcarbamoyl)-4-(3-chloro-benzoylamino)-butyric acid | CHEMBL421438 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H28ClN3O4 |
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| Mol. Mass. | 421.918 |
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| SMILES | OC(=O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NN1CCC2(CCCC2)CC1 |
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| Structure | 
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