Reaction Details |
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Target | Translocator protein |
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Ligand | BDBM50041500 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_37642 (CHEMBL650286) |
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IC50 | 6166±n/a nM |
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Citation | Greco, G; Novellino, E; Fiorini, I; Nacci, V; Campiani, G; Ciani, SM; Garofalo, A; Bernasconi, P; Mennini, T A comparative molecular field analysis model for 6-arylpyrrolo[2,1-d] [1,5]benzothiazepines binding selectively to the mitochondrial benzodiazepine receptor. J Med Chem37:4100-8 (1995) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Translocator protein |
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Name: | Translocator protein |
Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
Type: | Mitochondrion membrane protein |
Mol. Mass.: | 18945.84 |
Organism: | Rattus norvegicus (rat) |
Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
Residue: | 169 |
Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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BDBM50041500 |
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n/a |
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Name | BDBM50041500 |
Synonyms: | 5-(4-Methoxy-phenyl)-9-trifluoromethyl-6-thia-10b-aza-benzo[e]azulen-4-one | CHEMBL32268 |
Type | Small organic molecule |
Emp. Form. | C20H14F3NO2S |
Mol. Mass. | 389.391 |
SMILES | COc1ccc(cc1)C1Sc2ccc(cc2-n2cccc2C1=O)C(F)(F)F |
Structure |
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