Ki Summary

Reaction Details

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Target

5-hydroxytryptamine receptor 2A

Ligand

BDBM50031935

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2682 (CHEMBL617930)

240±n/a nM

Citation

Anzini, M; Cappelli, A; Vomero, S; Giorgi, G; Langer, T; Hamon, M; Merahi, N; Emerit, BM; Cagnotto, A; Skorupska, M Novel, potent, and selective 5-HT3 receptor antagonists based on the arylpiperazine skeleton: synthesis, structure, biological activity, and comparative molecular field analysis studies. J Med Chem38:2692-704 (1995) [PubMed]

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 2A

Name:

5-hydroxytryptamine receptor 2A

Synonyms:

5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

52852.05

Organism:

Rattus norvegicus (rat)

Description:

Rat cortex membranes 5-HT2A receptors.

Residue:

471

Sequence:

MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGY
LPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYK
SSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV

BDBM50031935

n/a

Name

BDBM50031935

Synonyms:

8-Methoxy-6-(4-methyl-piperazin-1-yl)-benzo[k]phenanthridine | CHEMBL291771

Type

Small organic molecule

Emp. Form.

C23H23N3O

Mol. Mass.

357.4482

SMILES

COc1cc2c(nc3ccccc3c2c2ccccc12)N1CCN(C)CC1

Structure