| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-K receptor |
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| Ligand | BDBM50291261 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_209368 (CHEMBL812062) |
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| Ki | 0.51±n/a nM |
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| Citation |  Giardina, GA; Sarau, HM; Farina, C; Medhurst, AD; Grugni, M; Foley, JJ; Raveglia, LF; Schmidt, DB; Rigolio, R; Vassallo, M; Vecchietti, V; Hay, DW 2-Phenyl-4-quinolinecarboxamides: a novel class of potent and selective non-peptide competitive antagonists for the human neurokinin-3 receptor. J Med Chem39:2281-4 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-K receptor |
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| Name: | Substance-K receptor |
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| Synonyms: | NK-2 receptor | NK-2R | NK2R_RAT | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | SKR | Substance-K receptor | Tac2r | Tachykinin receptor 2 | Tacr2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 43868.63 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Neurokinin NK2 TACR2 Murine::P16610 |
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| Residue: | 390 |
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| Sequence: | MGTRAIVSDANILSGLESNATGVTAFSMPGWQLALWATAYLALVLVAVTGNATVIWIILA
HERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGRAFCYFQNLFPITAMFVS
IYSMTAIAADRYMAIVHPFQPRLSAPSTKAIIAGIWLVALALASPQCFYSTITVDEGATK
CVVAWPNDNGGKMLLLYHLVVFVLIYFLPLLVMFGAYSVIGLTLWKRAVPRHQAHGANLR
HLQAKKKFVKAMVLVVLTFAICWLPYHLYFILGTFQEDIYYHKFIQQVYLALFWLAMSST
MYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEEDRLELTHTPSLSRRVNRCHTKETLFMT
GDMTHSEATNGQVGSPQDGEPAGPICKAQA
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| BDBM50291261 |
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| n/a |
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| Name | BDBM50291261 |
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| Synonyms: | (S)-(+)-N-((3-[1-Benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]prop-1-yl)-4-phenylpiperidin-4-yl)-N-methylacetamine | CHEMBL2311148 | CHEMBL346178 | N-(1-{3-[(R)-1-Benzoyl-3-(3,4-dichloro-phenyl)-piperidin-3-yl]-propyl}-4-phenyl-piperidin-4-yl)-N-methyl-acetamide | OSANETANT | SB-236984 | SR-14280 | SR-142801 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H41Cl2N3O2 |
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| Mol. Mass. | 606.625 |
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| SMILES | CN(C(C)=O)C1(CCN(CCC[C@@]2(CCCN(C2)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1)c1ccccc1 |r| |
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| Structure | 
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