| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Ligand | BDBM50054601 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_52873 (CHEMBL666232) |
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| IC50 | 30±n/a nM |
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| Citation |  Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R Synthesis, structure-activity relationships, and pharmacokinetic properties of dihydroorotate dehydrogenase inhibitors: 2-cyano-3-cyclopropyl-3-hydroxy-N-[3'-methyl-4'-(trifluoromethyl)phenyl ] propenamide and related compounds. J Med Chem39:4608-21 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Synonyms: | Dhodh | Dihydroorotate dehydrogenase | PYRD_MOUSE |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42711.08 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1366444 |
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| Residue: | 395 |
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| Sequence: | MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVR
VISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSV
TPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGIN
LGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQER
DALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTF
LGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR
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| BDBM50054601 |
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| n/a |
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| Name | BDBM50054601 |
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| Synonyms: | 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide | 5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide | 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide | Arava (TN) | CHEMBL960 | LEFLUNOMIDE | alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide |
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| Type | Small organic molecule |
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| Emp. Form. | C12H9F3N2O2 |
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| Mol. Mass. | 270.2073 |
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| SMILES | Cc1oncc1C(=O)Nc1ccc(cc1)C(F)(F)F |
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| Structure | 
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