Reaction Details |
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Target | Sigma non-opioid intracellular receptor 1 |
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Ligand | BDBM50054721 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_226554 (CHEMBL847751) |
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IC50 | 65±n/a nM |
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Citation | Matecka, D; Rothman, RB; Radesca, L; de Costa, BR; Dersch, CM; Partilla, JS; Pert, A; Glowa, JR; Wojnicki, FH; Rice, KC Development of novel, potent, and selective dopamine reuptake inhibitors through alteration of the piperazine ring of 1-[2-(diphenylmethoxy)ethyl]-and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909). J Med Chem39:4704-16 (1997) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sigma non-opioid intracellular receptor 1 |
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Name: | Sigma non-opioid intracellular receptor 1 |
Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 25124.85 |
Organism: | Homo sapiens (Human) |
Description: | Q99720 |
Residue: | 223 |
Sequence: | MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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BDBM50054721 |
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n/a |
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Name | BDBM50054721 |
Synonyms: | (2S,5R)-1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-2,5-dimethyl-piperazine | CHEMBL142518 |
Type | Small organic molecule |
Emp. Form. | C21H26F2N2O |
Mol. Mass. | 360.4407 |
SMILES | C[C@@H]1CN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)[C@@H](C)CN1 |
Structure |
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