| Reaction Details |
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 | Report a problem with these data |
| Target | Sigma non-opioid intracellular receptor 1 |
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| Ligand | BDBM50054753 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_226557 (CHEMBL847754) |
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| IC50 | 8.6±n/a nM |
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| Citation |  Matecka, D; Rothman, RB; Radesca, L; de Costa, BR; Dersch, CM; Partilla, JS; Pert, A; Glowa, JR; Wojnicki, FH; Rice, KC Development of novel, potent, and selective dopamine reuptake inhibitors through alteration of the piperazine ring of 1-[2-(diphenylmethoxy)ethyl]-and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909). J Med Chem39:4704-16 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sigma non-opioid intracellular receptor 1 |
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| Name: | Sigma non-opioid intracellular receptor 1 |
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| Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 25124.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q99720 |
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| Residue: | 223 |
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| Sequence: | MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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| BDBM50054753 |
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| n/a |
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| Name | BDBM50054753 |
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| Synonyms: | (2S,5R)-1-(2-Benzhydryloxy-ethyl)-2,5-dimethyl-4-(3-phenyl-propyl)-piperazine | CHEMBL140054 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H38N2O |
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| Mol. Mass. | 442.6355 |
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| SMILES | C[C@@H]1CN(CCOC(c2ccccc2)c2ccccc2)[C@@H](C)CN1CCCc1ccccc1 |
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| Structure | 
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