| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin receptor type B |
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| Ligand | BDBM50369274 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_64179 (CHEMBL671686) |
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| IC50 | 11000±n/a nM |
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| Citation |  Cody, WL; He, JX; Reily, MD; Haleen, SJ; Walker, DM; Reyner, EL; Stewart, BH; Doherty, AM Design of a potent combined pseudopeptide endothelin-A/endothelin-B receptor antagonist, Ac-DBhg16-Leu-Asp-Ile-[NMe]Ile-Trp21 (PD 156252): examination of its pharmacokinetic and spectral properties. J Med Chem40:2228-40 (1997) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin receptor type B |
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| Name: | Endothelin receptor type B |
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| Synonyms: | EDNRB_RAT | ENDOTHELIN B | ET-B | Ednrb | Endothelin receptor | Endothelin receptor non-selective type |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 49483.43 |
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| Organism: | RAT |
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| Description: | ENDOTHELIN B EDNRB RAT::P21451 |
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| Residue: | 442 |
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| Sequence: | MQSSASRCGRALVALLLACGLLGVWGEKRGFPPAQATPSLLGTKEVMTPPTKTSWTRGSN
SSLMRSSAPAEVTKGGRVAGVPPRSFPPPCQRKIEINKTFKYINTIVSCLVFVLGIIGNS
TLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINAYKLLAGDWPFGAEMCKLVPFI
QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGF
DVITSDYKGKPLRVCMLNPFQKTAFMQFYKTAKDWWLFSFYFCLPLAITAIFYTLMTCEM
LRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQSNPQRCEL
LSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQTFEEKQSLEEKQSC
LKFKANDHGYDNFRSSNKYSSS
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| BDBM50369274 |
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| n/a |
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| Name | BDBM50369274 |
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| Synonyms: | CHEMBL2367550 |
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| Type | Small organic molecule |
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| Emp. Form. | C51H67N7O10 |
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| Mol. Mass. | 938.1186 |
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| SMILES | [H][C@](C)(CC)[C@]([H])(NC(=O)[C@]([H])(CC(O)=O)NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@@]([H])(NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@]([H])(C(=O)N(C)[C@@]([H])(Cc1c[nH]c2ccccc12)C(O)=O)[C@@]([H])(C)CC |
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| Structure | 
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