Reaction Details |
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Target | Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha |
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Ligand | BDBM50065394 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_141224 (CHEMBL749440) |
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IC50 | 100±n/a nM |
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Citation | deSolms, SJ; Giuliani, EA; Graham, SL; Koblan, KS; Kohl, NE; Mosser, SD; Oliff, AI; Pompliano, DL; Rands, E; Scholz, TH; Wiscount, CM; Gibbs, JB; Smith, RL N-Arylalkyl pseudopeptide inhibitors of farnesyltransferase. J Med Chem41:2651-6 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha |
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Name: | Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha |
Synonyms: | Protein farnesyltransferase | Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of EBI is 38702 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha |
Synonyms: | CAAX farnesyltransferase subunit alpha | FNTA_MOUSE | FTase-alpha | Fnta | GGTase-I-alpha | Geranylgeranyl transferase type 1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Ras proteins prenyltransferase subunit alpha | Type I protein geranyl-geranyltransferase subunit alpha |
Type: | PROTEIN |
Mol. Mass.: | 43994.09 |
Organism: | Mus musculus |
Description: | EBI_10570 |
Residue: | 377 |
Sequence: | MAATEGVGESAAGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDS
PTYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLT
RDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYITAIIEEQPKNYQVWHHRRVLVEWLK
DPSQELEFIADILSQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQR
HFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLL
DLQPSHSSPYLIAFLVDVYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIG
RSLQSKHCRESDIPASV
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Component 2 |
Name: | Protein farnesyltransferase subunit beta |
Synonyms: | FNTB_MOUSE | Fntb | Protein farnesyltransferase |
Type: | PROTEIN |
Mol. Mass.: | 48811.61 |
Organism: | Mus musculus |
Description: | EBI_12341 |
Residue: | 437 |
Sequence: | MASSSSFTYYCPPSSSPVWSEPLYSLRPEHVRERLQDDSVETVTSIEQAKVEEKIQEVFS
SYKFNHLVPRLILQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQ
IVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQY
LYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIG
GVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCY
SFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDF
YHTCYCLSGLSIAQHFGSGAMLHDMVMGVPENVLQPTHPVYNIGPEKVIQATTHFLQKPV
PGFEECEDEVTSDPATD
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BDBM50065394 |
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n/a |
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Name | BDBM50065394 |
Synonyms: | (S)-2-(2-{[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-pentyl]-benzyl-amino}-acetylamino)-4-methylsulfanyl-butyric acid methyl ester | CHEMBL89605 |
Type | Small organic molecule |
Emp. Form. | C24H42N4O3S2 |
Mol. Mass. | 498.745 |
SMILES | CCC(C)[C@@H](CN(CC(=O)N[C@@H](CCSC)C(=O)OC)Cc1ccccc1)NC[C@@H](N)CS |
Structure |
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