Reaction Details |
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Target | Neutrophil collagenase |
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Ligand | BDBM50077385 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_105812 (CHEMBL717812) |
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IC50 | 20±n/a nM |
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Citation | Matter, H; Schwab, W; Barbier, D; Billen, G; Haase, B; Neises, B; Schudok, M; Thorwart, W; Schreuder, H; Brachvogel, V; Lönze, P; Weithmann, KU Quantitative structure-activity relationship of human neutrophil collagenase (MMP-8) inhibitors using comparative molecular field analysis and X-ray structure analysis. J Med Chem42:1908-20 (1999) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Neutrophil collagenase |
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Name: | Neutrophil collagenase |
Synonyms: | CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL |
Type: | Enzyme |
Mol. Mass.: | 53413.48 |
Organism: | Homo sapiens (Human) |
Description: | P22894 |
Residue: | 467 |
Sequence: | MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV
EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY
TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL
AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD
RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG
YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
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BDBM50077385 |
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n/a |
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Name | BDBM50077385 |
Synonyms: | CHEMBL301626 | [(R)-2-(4'-Fluoro-biphenyl-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-oxo-acetic acid |
Type | Small organic molecule |
Emp. Form. | C23H18FNO5S |
Mol. Mass. | 439.456 |
SMILES | OC(=O)C(=O)[C@H]1Cc2ccccc2CN1S(=O)(=O)c1ccc(cc1)-c1ccc(F)cc1 |
Structure |
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