Compile Data Set for Download or QSAR

Found 94 hits with Last Name = 'weithmann' and Initial = 'ku'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077404 (CHEMBL300162 | [(R)-2-(4'-Dimethylamino-biphenyl-4...) Show SMILES CN(C)c1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1Cc2ccccc2C[C@@H]1C(=O)C(O)=O Show InChI InChI=1S/C25H24N2O5S/c1-26(2)21-11-7-17(8-12-21)18-9-13-22(14-10-18)33(31,32)27-16-20-6-4-3-5-19(20)15-23(27)24(28)25(29)30/h3-14,23H,15-16H2,1-2H3,(H,29,30)/t23-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077433 ((R)-7-Hydroxy-2-(4-methoxy-benzenesulfonyl)-1,2,3,...) Show SMILES COc1ccc(cc1)S(=O)(=O)N1Cc2cc(O)ccc2C[C@@H]1C(=O)NO Show InChI InChI=1S/C17H18N2O6S/c1-25-14-4-6-15(7-5-14)26(23,24)19-10-12-8-13(20)3-2-11(12)9-16(19)17(21)18-22/h2-8,16,20,22H,9-10H2,1H3,(H,18,21)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077422 ((R)-2-(5-Pyridin-2-yl-thiophen-2-ylmethanesulfonyl...) Show SMILES ONC(=O)[C@H]1Cc2ccccc2CN1S(=O)(=O)Cc1ccc(s1)-c1ccccn1 Show InChI InChI=1S/C20H19N3O4S2/c24-20(22-25)18-11-14-5-1-2-6-15(14)12-23(18)29(26,27)13-16-8-9-19(28-16)17-7-3-4-10-21-17/h1-10,18,25H,11-13H2,(H,22,24)/t18-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077416 ((R)-2-(4'-Dimethylamino-biphenyl-4-sulfonyl)-1,2,3...) Show SMILES CN(C)c1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N1Cc2ccccc2C[C@@H]1C(=O)NO Show InChI InChI=1S/C24H25N3O4S/c1-26(2)21-11-7-17(8-12-21)18-9-13-22(14-10-18)32(30,31)27-16-20-6-4-3-5-19(20)15-23(27)24(28)25-29/h3-14,23,29H,15-16H2,1-2H3,(H,25,28)/t23-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077411 ((R)-2-[4-(4-Dimethylamino-phenoxy)-benzenesulfonyl...) Show SMILES CN(C)c1ccc(Oc2ccc(cc2)S(=O)(=O)N2Cc3ccccc3C[C@@H]2C(=O)NO)cc1 Show InChI InChI=1S/C24H25N3O5S/c1-26(2)19-7-9-20(10-8-19)32-21-11-13-22(14-12-21)33(30,31)27-16-18-6-4-3-5-17(18)15-23(27)24(28)25-29/h3-14,23,29H,15-16H2,1-2H3,(H,25,28)/t23-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077387 ((R)-2-(4-Butoxy-benzenesulfonyl)-1,2,3,4-tetrahydr...) Show SMILES CCCCOc1ccc(cc1)S(=O)(=O)N1Cc2ccccc2C[C@@H]1C(=O)NO Show InChI InChI=1S/C20H24N2O5S/c1-2-3-12-27-17-8-10-18(11-9-17)28(25,26)22-14-16-7-5-4-6-15(16)13-19(22)20(23)21-24/h4-11,19,24H,2-3,12-14H2,1H3,(H,21,23)/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077440 (CHEMBL56137 | {(S)-1-[(S)-3-Hydroxycarbamoyl-2-(4-...) Show SMILES COc1ccc(cc1)S(=O)(=O)N1Cc2cc(NC(=O)[C@H](C)NC(=O)OC(C)(C)C)ccc2C[C@H]1C(=O)NO Show InChI InChI=1S/C25H32N4O8S/c1-15(26-24(32)37-25(2,3)4)22(30)27-18-7-6-16-13-21(23(31)28-33)29(14-17(16)12-18)38(34,35)20-10-8-19(36-5)9-11-20/h6-12,15,21,33H,13-14H2,1-5H3,(H,26,32)(H,27,30)(H,28,31)/t15-,21-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077390 ((R)-2-(4-Phenoxy-benzenesulfonyl)-1,2,3,4-tetrahyd...) Show SMILES ONC(=O)[C@H]1Cc2ccccc2CN1S(=O)(=O)c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C22H20N2O5S/c25-22(23-26)21-14-16-6-4-5-7-17(16)15-24(21)30(27,28)20-12-10-19(11-13-20)29-18-8-2-1-3-9-18/h1-13,21,26H,14-15H2,(H,23,25)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077438 ((R)-2-[4-(4-Fluoro-benzyloxy)-benzenesulfonyl]-1,2...) Show SMILES ONC(=O)[C@H]1Cc2ccccc2CN1S(=O)(=O)c1ccc(OCc2ccc(F)cc2)cc1 Show InChI InChI=1S/C23H21FN2O5S/c24-19-7-5-16(6-8-19)15-31-20-9-11-21(12-10-20)32(29,30)26-14-18-4-2-1-3-17(18)13-22(26)23(27)25-28/h1-12,22,28H,13-15H2,(H,25,27)/t22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077370 (CHEMBL301675 | Carbonic acid ethyl ester (R)-3-hyd...) Show SMILES CCOC(=O)Oc1ccc2C[C@@H](N(Cc2c1)S(=O)(=O)c1ccc(OC)cc1)C(=O)NO Show InChI InChI=1S/C20H22N2O8S/c1-3-29-20(24)30-16-5-4-13-11-18(19(23)21-25)22(12-14(13)10-16)31(26,27)17-8-6-15(28-2)7-9-17/h4-10,18,25H,3,11-12H2,1-2H3,(H,21,23)/t18-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077444 ((R)-7-Amino-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-...) Show SMILES COc1ccc(cc1)S(=O)(=O)N1Cc2cc(N)ccc2C[C@@H]1C(=O)NO Show InChI InChI=1S/C17H19N3O5S/c1-25-14-4-6-15(7-5-14)26(23,24)20-10-12-8-13(18)3-2-11(12)9-16(20)17(21)19-22/h2-8,16,22H,9-10,18H2,1H3,(H,19,21)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077373 ((R)-7-Amino-2-(4'-fluoro-biphenyl-4-sulfonyl)-1,2,...) Show SMILES Nc1ccc2C[C@@H](N(Cc2c1)S(=O)(=O)c1ccc(cc1)-c1ccc(F)cc1)C(=O)NO Show InChI InChI=1S/C22H20FN3O4S/c23-18-6-1-14(2-7-18)15-4-9-20(10-5-15)31(29,30)26-13-17-11-19(24)8-3-16(17)12-21(26)22(27)25-28/h1-11,21,28H,12-13,24H2,(H,25,27)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077395 ((R)-2-(Biphenyl-4-sulfonyl)-1,2,3,4-tetrahydro-iso...) Show SMILES ONC(=O)[C@H]1Cc2ccccc2CN1S(=O)(=O)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C22H20N2O4S/c25-22(23-26)21-14-18-8-4-5-9-19(18)15-24(21)29(27,28)20-12-10-17(11-13-20)16-6-2-1-3-7-16/h1-13,21,26H,14-15H2,(H,23,25)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077389 ((R)-2-(4-Benzoyl-benzenesulfonyl)-1,2,3,4-tetrahyd...) Show SMILES ONC(=O)[C@H]1Cc2ccccc2CN1S(=O)(=O)c1ccc(cc1)C(=O)c1ccccc1 Show InChI InChI=1S/C23H20N2O5S/c26-22(16-6-2-1-3-7-16)17-10-12-20(13-11-17)31(29,30)25-15-19-9-5-4-8-18(19)14-21(25)23(27)24-28/h1-13,21,28H,14-15H2,(H,24,27)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077445 (CHEMBL60579 | [(R)-3-Hydroxycarbamoyl-2-(4-methoxy...) Show SMILES COc1ccc(cc1)S(=O)(=O)N1Cc2cc(NC(=O)OC(C)(C)C)ccc2C[C@@H]1C(=O)NO Show InChI InChI=1S/C22H27N3O7S/c1-22(2,3)32-21(27)23-16-6-5-14-12-19(20(26)24-28)25(13-15(14)11-16)33(29,30)18-9-7-17(31-4)8-10-18/h5-11,19,28H,12-13H2,1-4H3,(H,23,27)(H,24,26)/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077393 ((R)-5-(4-Methoxy-benzenesulfonyl)-1-methyl-4,5,6,7...) Show SMILES COc1ccc(cc1)S(=O)(=O)N1Cc2ncn(C)c2C[C@@H]1C(=O)NO Show InChI InChI=1S/C15H18N4O5S/c1-18-9-16-12-8-19(14(7-13(12)18)15(20)17-21)25(22,23)11-5-3-10(24-2)4-6-11/h3-6,9,14,21H,7-8H2,1-2H3,(H,17,20)/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077368 ((R)-2-(4'-Chloro-biphenyl-4-sulfonyl)-1,2,3,4-tetr...) Show SMILES ONC(=O)[C@H]1Cc2ccccc2CN1S(=O)(=O)c1ccc(cc1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C22H19ClN2O4S/c23-19-9-5-15(6-10-19)16-7-11-20(12-8-16)30(28,29)25-14-18-4-2-1-3-17(18)13-21(25)22(26)24-27/h1-12,21,27H,13-14H2,(H,24,26)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077450 ((R)-2-(4-Methoxy-benzenesulfonyl)-2,3,4,9-tetrahyd...) Show SMILES COc1ccc(cc1)S(=O)(=O)N1Cc2[nH]c3ccccc3c2C[C@@H]1C(=O)NO Show InChI InChI=1S/C19H19N3O5S/c1-27-12-6-8-13(9-7-12)28(25,26)22-11-17-15(10-18(22)19(23)21-24)14-4-2-3-5-16(14)20-17/h2-9,18,20,24H,10-11H2,1H3,(H,21,23)/t18-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077443 ((R)-5-(4-Methoxy-benzenesulfonyl)-4,5,6,7-tetrahyd...) Show SMILES COc1ccc(cc1)S(=O)(=O)N1Cc2[nH]cnc2C[C@@H]1C(=O)NO Show InChI InChI=1S/C14H16N4O5S/c1-23-9-2-4-10(5-3-9)24(21,22)18-7-12-11(15-8-16-12)6-13(18)14(19)17-20/h2-5,8,13,20H,6-7H2,1H3,(H,15,16)(H,17,19)/t13-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077399 ((R)-2-(4-Methoxy-benzenesulfonyl)-1,2,3,4-tetrahyd...) Show SMILES COc1ccc(cc1)S(=O)(=O)N1Cc2ccccc2C[C@@H]1C(=O)NO Show InChI InChI=1S/C17H18N2O5S/c1-24-14-6-8-15(9-7-14)25(22,23)19-11-13-5-3-2-4-12(13)10-16(19)17(20)18-21/h2-9,16,21H,10-11H2,1H3,(H,18,20)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077374 (CHEMBL294167 | [(R)-2-(4'-Chloro-biphenyl-4-sulfon...) Show SMILES OC(=O)C(=O)[C@H]1Cc2ccccc2CN1S(=O)(=O)c1ccc(cc1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C23H18ClNO5S/c24-19-9-5-15(6-10-19)16-7-11-20(12-8-16)31(29,30)25-14-18-4-2-1-3-17(18)13-21(25)22(26)23(27)28/h1-12,21H,13-14H2,(H,27,28)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077435 ((S)-7-((S)-2-Amino-propionylamino)-2-(4-methoxy-be...) Show SMILES COc1ccc(cc1)S(=O)(=O)N1Cc2cc(NC(=O)[C@H](C)N)ccc2C[C@H]1C(=O)NO Show InChI InChI=1S/C20H24N4O6S/c1-12(21)19(25)22-15-4-3-13-10-18(20(26)23-27)24(11-14(13)9-15)31(28,29)17-7-5-16(30-2)6-8-17/h3-9,12,18,27H,10-11,21H2,1-2H3,(H,22,25)(H,23,26)/t12-,18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077406 (CHEMBL57746 | [(R)-7-Amino-2-(4'-chloro-biphenyl-4...) Show SMILES Nc1ccc2C[C@@H](N(Cc2c1)S(=O)(=O)c1ccc(cc1)-c1ccc(Cl)cc1)C(=O)C(O)=O Show InChI InChI=1S/C23H19ClN2O5S/c24-18-6-1-14(2-7-18)15-4-9-20(10-5-15)32(30,31)26-13-17-11-19(25)8-3-16(17)12-21(26)22(27)23(28)29/h1-11,21H,12-13,25H2,(H,28,29)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077401 ((R)-2-(4-Phenoxy-benzenesulfonyl)-2,3,4,9-tetrahyd...) Show SMILES ONC(=O)[C@H]1Cc2c(CN1S(=O)(=O)c1ccc(Oc3ccccc3)cc1)[nH]c1ccccc21 Show InChI InChI=1S/C24H21N3O5S/c28-24(26-29)23-14-20-19-8-4-5-9-21(19)25-22(20)15-27(23)33(30,31)18-12-10-17(11-13-18)32-16-6-2-1-3-7-16/h1-13,23,25,29H,14-15H2,(H,26,28)/t23-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase, Matrix Metalloprotease-8				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077410 ((R)-2-(5-Isoxazol-3-yl-thiophene-2-sulfonyl)-1,2,3...) Show SMILES ONC(=O)[C@H]1Cc2ccccc2CN1S(=O)(=O)c1ccc(s1)-c1ccon1 Show InChI InChI=1S/C17H15N3O5S2/c21-17(18-22)14-9-11-3-1-2-4-12(11)10-20(14)27(23,24)16-6-5-15(26-16)13-7-8-25-19-13/h1-8,14,22H,9-10H2,(H,18,21)/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Collagenase 3 (Homo sapiens (Human))	BDBM16596 (4-N,6-N-bis[(4-fluoro-3-methylphenyl)methyl]pyrimi...) Show SMILES Cc1cc(CNC(=O)c2cc(ncn2)C(=O)NCc2ccc(F)c(C)c2)ccc1F Show InChI InChI=1S/C22H20F2N4O2/c1-13-7-15(3-5-17(13)23)10-25-21(29)19-9-20(28-12-27-19)22(30)26-11-16-4-6-18(24)14(2)8-16/h3-9,12H,10-11H2,1-2H3,(H,25,29)(H,26,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	7.5	22
Aventis Pharma Deutschland GmbH					Assay Description MMP-13 was assayed its proteolytic activity using a quenched fluorogenic substrate. The substrate hydrolysis was monitored by recording the increase ...				Chem Biol 12: 181-9 (2005) Article DOI: 10.1016/j.chembiol.2004.11.014 BindingDB Entry DOI: 10.7270/Q2WD3XTW
					More data for this Ligand-Target Pair				3D Structure (crystal)
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077402 (4-Methoxy-benzenesulfonic acid (R)-3-hydroxycarbam...) Show SMILES COc1ccc(cc1)S(=O)(=O)Oc1ccc2C[C@@H](N(Cc2c1)S(=O)(=O)c1ccc(OC)cc1)C(=O)NO Show InChI InChI=1S/C24H24N2O9S2/c1-33-18-5-9-21(10-6-18)36(29,30)26-15-17-13-20(4-3-16(17)14-23(26)24(27)25-28)35-37(31,32)22-11-7-19(34-2)8-12-22/h3-13,23,28H,14-15H2,1-2H3,(H,25,27)/t23-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077403 ((R)-2-(4-Methoxy-benzenesulfonyl)-7-nitro-1,2,3,4-...) Show SMILES COc1ccc(cc1)S(=O)(=O)N1Cc2cc(ccc2C[C@@H]1C(=O)NO)[N+]([O-])=O Show InChI InChI=1S/C17H17N3O7S/c1-27-14-4-6-15(7-5-14)28(25,26)19-10-12-8-13(20(23)24)3-2-11(12)9-16(19)17(21)18-22/h2-8,16,22H,9-10H2,1H3,(H,18,21)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077365 (CHEMBL417945 | Oxo-[(R)-2-(4-phenoxy-benzenesulfon...) Show SMILES OC(=O)C(=O)[C@H]1Cc2ccccc2CN1S(=O)(=O)c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C23H19NO6S/c25-22(23(26)27)21-14-16-6-4-5-7-17(16)15-24(21)31(28,29)20-12-10-19(11-13-20)30-18-8-2-1-3-9-18/h1-13,21H,14-15H2,(H,26,27)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077409 (CHEMBL301048 | Oxo-[(R)-2-(4'-trifluoromethyl-biph...) Show SMILES OC(=O)C(=O)[C@H]1Cc2ccccc2CN1S(=O)(=O)c1ccc(cc1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C24H18F3NO5S/c25-24(26,27)19-9-5-15(6-10-19)16-7-11-20(12-8-16)34(32,33)28-14-18-4-2-1-3-17(18)13-21(28)22(29)23(30)31/h1-12,21H,13-14H2,(H,30,31)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077394 (CHEMBL294426 | [(R)-2-(4'-Fluoro-biphenyl-4-sulfon...) Show SMILES CC(C)(C)OC(=O)Nc1ccc2C[C@@H](N(Cc2c1)S(=O)(=O)c1ccc(cc1)-c1ccc(F)cc1)C(=O)NO Show InChI InChI=1S/C27H28FN3O6S/c1-27(2,3)37-26(33)29-22-11-6-19-15-24(25(32)30-34)31(16-20(19)14-22)38(35,36)23-12-7-18(8-13-23)17-4-9-21(28)10-5-17/h4-14,24,34H,15-16H2,1-3H3,(H,29,33)(H,30,32)/t24-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077381 ((R)-2-(Dibenzofuran-2-sulfonyl)-1,2,3,4-tetrahydro...) Show SMILES ONC(=O)[C@H]1Cc2ccccc2CN1S(=O)(=O)c1ccc2oc3ccccc3c2c1 Show InChI InChI=1S/C22H18N2O5S/c25-22(23-26)19-11-14-5-1-2-6-15(14)13-24(19)30(27,28)16-9-10-21-18(12-16)17-7-3-4-8-20(17)29-21/h1-10,12,19,26H,11,13H2,(H,23,25)/t19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077449 ((S)-3-Benzyloxycarbonylamino-N-[(S)-3-hydroxycarba...) Show SMILES COc1ccc(cc1)S(=O)(=O)N1Cc2cc(NC(=O)[C@H](CC(=O)OC(C)(C)C)NC(=O)OCc3ccccc3)ccc2C[C@H]1C(=O)NO Show InChI InChI=1S/C33H38N4O10S/c1-33(2,3)47-29(38)18-27(35-32(41)46-20-21-8-6-5-7-9-21)30(39)34-24-11-10-22-17-28(31(40)36-42)37(19-23(22)16-24)48(43,44)26-14-12-25(45-4)13-15-26/h5-16,27-28,42H,17-20H2,1-4H3,(H,34,39)(H,35,41)(H,36,40)/t27-,28-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077431 (CHEMBL55752 | {(R)-2-[4-(4-Cyano-phenoxy)-benzenes...) Show SMILES OC(=O)C(=O)[C@H]1Cc2ccccc2CN1S(=O)(=O)c1ccc(Oc2ccc(cc2)C#N)cc1 Show InChI InChI=1S/C24H18N2O6S/c25-14-16-5-7-19(8-6-16)32-20-9-11-21(12-10-20)33(30,31)26-15-18-4-2-1-3-17(18)13-22(26)23(27)24(28)29/h1-12,22H,13,15H2,(H,28,29)/t22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077426 (CHEMBL57414 | [(R)-2-(Biphenyl-4-sulfonyl)-1,2,3,4...) Show SMILES OC(=O)C(=O)[C@H]1Cc2ccccc2CN1S(=O)(=O)c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C23H19NO5S/c25-22(23(26)27)21-14-18-8-4-5-9-19(18)15-24(21)30(28,29)20-12-10-17(11-13-20)16-6-2-1-3-7-16/h1-13,21H,14-15H2,(H,26,27)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077447 ((R)-2-Benzenesulfonyl-1,2,3,4-tetrahydro-isoquinol...) Show SMILES ONC(=O)[C@H]1Cc2ccccc2CN1S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C16H16N2O4S/c19-16(17-20)15-10-12-6-4-5-7-13(12)11-18(15)23(21,22)14-8-2-1-3-9-14/h1-9,15,20H,10-11H2,(H,17,19)/t15-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077415 (CHEMBL56845 | [(R)-2-(4'-Chloro-biphenyl-4-sulfony...) Show SMILES OC(=O)C(=O)[C@H]1Cc2cc(ccc2CN1S(=O)(=O)c1ccc(cc1)-c1ccc(Cl)cc1)[N+]([O-])=O Show InChI InChI=1S/C23H17ClN2O7S/c24-18-6-1-14(2-7-18)15-4-9-20(10-5-15)34(32,33)25-13-16-3-8-19(26(30)31)11-17(16)12-21(25)22(27)23(28)29/h1-11,21H,12-13H2,(H,28,29)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077377 (CHEMBL301900 | [(R)-2-(4'-Chloro-biphenyl-4-sulfon...) Show SMILES OC(=O)C(=O)[C@H]1Cc2ccc(O)cc2CN1S(=O)(=O)c1ccc(cc1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C23H18ClNO6S/c24-18-6-1-14(2-7-18)15-4-9-20(10-5-15)32(30,31)25-13-17-11-19(26)8-3-16(17)12-21(25)22(27)23(28)29/h1-11,21,26H,12-13H2,(H,28,29)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077446 (CHEMBL55453 | [(R)-2-(2-Biphenyl-4-yl-ethanesulfon...) Show SMILES OC(=O)C(=O)[C@H]1Cc2ccccc2CN1S(=O)(=O)CCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C25H23NO5S/c27-24(25(28)29)23-16-21-8-4-5-9-22(21)17-26(23)32(30,31)15-14-18-10-12-20(13-11-18)19-6-2-1-3-7-19/h1-13,23H,14-17H2,(H,28,29)/t23-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077385 (CHEMBL301626 | [(R)-2-(4'-Fluoro-biphenyl-4-sulfon...) Show SMILES OC(=O)C(=O)[C@H]1Cc2ccccc2CN1S(=O)(=O)c1ccc(cc1)-c1ccc(F)cc1 Show InChI InChI=1S/C23H18FNO5S/c24-19-9-5-15(6-10-19)16-7-11-20(12-8-16)31(29,30)25-14-18-4-2-1-3-17(18)13-21(25)22(26)23(27)28/h1-12,21H,13-14H2,(H,27,28)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077382 (CHEMBL291697 | [(R)-2-(4'-Fluoro-biphenyl-4-sulfon...) Show SMILES OC(=O)C(=O)[C@H]1Cc2cc(ccc2CN1S(=O)(=O)c1ccc(cc1)-c1ccc(F)cc1)[N+]([O-])=O Show InChI InChI=1S/C23H17FN2O7S/c24-18-6-1-14(2-7-18)15-4-9-20(10-5-15)34(32,33)25-13-16-3-8-19(26(30)31)11-17(16)12-21(25)22(27)23(28)29/h1-11,21H,12-13H2,(H,28,29)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077396 ((R)-2-[5-(2-Methylsulfanyl-pyrimidin-4-yl)-thiophe...) Show SMILES CSc1nccc(n1)-c1ccc(s1)S(=O)(=O)N1Cc2ccccc2C[C@@H]1C(=O)NO Show InChI InChI=1S/C19H18N4O4S3/c1-28-19-20-9-8-14(21-19)16-6-7-17(29-16)30(26,27)23-11-13-5-3-2-4-12(13)10-15(23)18(24)22-25/h2-9,15,25H,10-11H2,1H3,(H,22,24)/t15-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077407 ((R)-2-(2-Phenyl-ethanesulfonyl)-1,2,3,4-tetrahydro...) Show SMILES ONC(=O)[C@H]1Cc2ccccc2CN1S(=O)(=O)CCc1ccccc1 Show InChI InChI=1S/C18H20N2O4S/c21-18(19-22)17-12-15-8-4-5-9-16(15)13-20(17)25(23,24)11-10-14-6-2-1-3-7-14/h1-9,17,22H,10-13H2,(H,19,21)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077432 (CHEMBL294654 | {(R)-2-[4-(4-Chloro-phenoxy)-benzen...) Show SMILES OC(=O)C(=O)[C@H]1Cc2ccccc2CN1S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C23H18ClNO6S/c24-17-5-7-18(8-6-17)31-19-9-11-20(12-10-19)32(29,30)25-14-16-4-2-1-3-15(16)13-21(25)22(26)23(27)28/h1-12,21H,13-14H2,(H,27,28)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077400 (CHEMBL298957 | [4-((R)-3-Hydroxycarbamoyl-3,4-dihy...) Show SMILES CCOC(=O)Nc1ccc(cc1)S(=O)(=O)N1Cc2ccccc2C[C@@H]1C(=O)NO Show InChI InChI=1S/C19H21N3O6S/c1-2-28-19(24)20-15-7-9-16(10-8-15)29(26,27)22-12-14-6-4-3-5-13(14)11-17(22)18(23)21-25/h3-10,17,25H,2,11-12H2,1H3,(H,20,24)(H,21,23)/t17-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077364 (CHEMBL56158 | [(R)-6-tert-Butoxycarbonylamino-2-(4...) Show SMILES CC(C)(C)OC(=O)Nc1ccc2CN([C@H](Cc2c1)C(=O)C(O)=O)S(=O)(=O)c1ccc(cc1)-c1ccc(F)cc1 Show InChI InChI=1S/C28H27FN2O7S/c1-28(2,3)38-27(35)30-22-11-6-19-16-31(24(15-20(19)14-22)25(32)26(33)34)39(36,37)23-12-7-18(8-13-23)17-4-9-21(29)10-5-17/h4-14,24H,15-16H2,1-3H3,(H,30,35)(H,33,34)/t24-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077423 (CHEMBL293571 | [(R)-2-(4'-Chloro-biphenyl-4-sulfon...) Show SMILES OC(=O)C(=O)[C@H]1Cc2ccc(cc2CN1S(=O)(=O)c1ccc(cc1)-c1ccc(Cl)cc1)[N+]([O-])=O Show InChI InChI=1S/C23H17ClN2O7S/c24-18-6-1-14(2-7-18)15-4-9-20(10-5-15)34(32,33)25-13-17-11-19(26(30)31)8-3-16(17)12-21(25)22(27)23(28)29/h1-11,21H,12-13H2,(H,28,29)/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077379 ((R)-2-(2-Pyridin-4-yl-ethanesulfonyl)-1,2,3,4-tetr...) Show SMILES ONC(=O)[C@H]1Cc2ccccc2CN1S(=O)(=O)CCc1ccncc1 Show InChI InChI=1S/C17H19N3O4S/c21-17(19-22)16-11-14-3-1-2-4-15(14)12-20(16)25(23,24)10-7-13-5-8-18-9-6-13/h1-6,8-9,16,22H,7,10-12H2,(H,19,21)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077367 (CHEMBL55321 | {(R)-2-[4-(4-Fluoro-benzyloxy)-benze...) Show SMILES OC(=O)C(=O)[C@H]1Cc2ccccc2CN1S(=O)(=O)c1ccc(OCc2ccc(F)cc2)cc1 Show InChI InChI=1S/C24H20FNO6S/c25-19-7-5-16(6-8-19)15-32-20-9-11-21(12-10-20)33(30,31)26-14-18-4-2-1-3-17(18)13-22(26)23(27)24(28)29/h1-12,22H,13-15H2,(H,28,29)/t22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50077448 (CHEMBL299720 | {(R)-2-[4-(4-Dimethylamino-phenoxy)...) Show SMILES CN(C)c1ccc(Oc2ccc(cc2)S(=O)(=O)N2Cc3ccccc3C[C@@H]2C(=O)C(O)=O)cc1 Show InChI InChI=1S/C25H24N2O6S/c1-26(2)19-7-9-20(10-8-19)33-21-11-13-22(14-12-21)34(31,32)27-16-18-6-4-3-5-17(18)15-23(27)24(28)25(29)30/h3-14,23H,15-16H2,1-2H3,(H,29,30)/t23-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase [Matrix Metalloprotease-8, MMP-8]				J Med Chem 42: 1908-20 (1999) Article DOI: 10.1021/jm980631s BindingDB Entry DOI: 10.7270/Q2251JV5
					More data for this Ligand-Target Pair

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