Reaction Details |
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Target | Sodium- and chloride-dependent GABA transporter 1 |
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Ligand | BDBM50080361 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_202725 (CHEMBL807623) |
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Ki | 132±n/a nM |
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Citation | Knutsen, LJ; Andersen, KE; Lau, J; Lundt, BF; Henry, RF; Morton, HE; Naerum, L; Petersen, H; Stephensen, H; Suzdak, PD; Swedberg, MD; Thomsen, C; Sørensen, PO Synthesis of novel GABA uptake inhibitors. 3. Diaryloxime and diarylvinyl ether derivatives of nipecotic acid and guvacine as anticonvulsant agents. J Med Chem42:3447-62 (1999) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium- and chloride-dependent GABA transporter 1 |
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Name: | Sodium- and chloride-dependent GABA transporter 1 |
Synonyms: | GABA transporter | Gabt1 | Gat-1 | Gat1 | SC6A1_RAT | Slc6a1 | Solute carrier family 6 member 1 |
Type: | PROTEIN |
Mol. Mass.: | 67006.26 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_1472611 |
Residue: | 599 |
Sequence: | MATDNSKVADGQISTEVSEAPVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGY
AIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAP
MFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLV
NTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVV
YFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGL
GSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASG
PGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRR
ELFIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRF
YDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLM
ALSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPSEDIVRPENGPEQPQAGSSASKEAYI
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BDBM50080361 |
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n/a |
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Name | BDBM50080361 |
Synonyms: | (R)-1-{2-[2,2-Bis-(2,4-difluoro-phenyl)-vinyloxy]-ethyl}-piperidine-3-carboxylic acid; hydrochloride | CHEMBL545514 |
Type | Small organic molecule |
Emp. Form. | C22H21F4NO3 |
Mol. Mass. | 423.4007 |
SMILES | [#8]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7](-[#6]-[#6]-[#8]\[#6]=[#6](/c2ccc(F)cc2F)-c2ccc(F)cc2F)-[#6]-1 |
Structure |
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