| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neutrophil collagenase |
|---|
| Ligand | BDBM50082564 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_105065 (CHEMBL711311) |
|---|
| IC50 | 1.9±n/a nM |
|---|
| Citation |  Almstead, NG; Bradley, RS; Pikul, S; De, B; Natchus, MG; Taiwo, YO; Gu, F; Williams, LE; Hynd, BA; Janusz, MJ; Dunaway, CM; Mieling, GE Design, synthesis, and biological evaluation of potent thiazine- and thiazepine-based matrix metalloproteinase inhibitors. J Med Chem42:4547-62 (1999) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neutrophil collagenase |
|---|
| Name: | Neutrophil collagenase |
|---|
| Synonyms: | CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 53413.48 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P22894 |
|---|
| Residue: | 467 |
|---|
| Sequence: | MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIV
EKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNY
TPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGIL
AHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKD
RYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG
YPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGI
ESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
|
|
|
|---|
| BDBM50082564 |
|---|
| n/a |
|---|
| Name | BDBM50082564 |
|---|
| Synonyms: | (R)-1-(4-Methoxy-benzenesulfonyl)-3,3-dimethyl-azepane-2-carboxylic acid hydroxyamide | CHEMBL140152 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H24N2O5S |
|---|
| Mol. Mass. | 356.437 |
|---|
| SMILES | COc1ccc(cc1)S(=O)(=O)N1CCCCC(C)(C)[C@@H]1C(=O)NO |
|---|
| Structure | 
|
|---|
Search and Browse
