Reaction Details |
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Target | 5-hydroxytryptamine receptor 1A |
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Ligand | BDBM50083290 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1432 (CHEMBL616306) |
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Ki | 10±n/a nM |
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Citation | Abou-Gharbia, MA; Childers, WE; Fletcher, H; McGaughey, G; Patel, U; Webb, MB; Yardley, J; Andree, T; Boast, C; Kucharik, RJ; Marquis, K; Morris, H; Scerni, R; Moyer, JA Synthesis and SAR of adatanserin: novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT(1A) and 5-HT(2) activity as potential anxiolytic and antidepressant agents. J Med Chem42:5077-94 (2000) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 1A |
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Name: | 5-hydroxytryptamine receptor 1A |
Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46445.29 |
Organism: | Rattus norvegicus (rat) |
Description: | Binding assays were performed using rat hippocampal membranes. |
Residue: | 422 |
Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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BDBM50083290 |
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n/a |
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Name | BDBM50083290 |
Synonyms: | CHEMBL544630 | Hexahydro-2,5-methano-pentalene-3a-carboxylic acid {3-[4-(3-chloro-phenyl)-piperazin-1-yl]-propyl}-amide; dihydrochloride |
Type | Small organic molecule |
Emp. Form. | C23H32ClN3O |
Mol. Mass. | 401.973 |
SMILES | Clc1cccc(c1)N1CCN(CCCNC(=O)C23CC4C[C@@H]2C[C@@H](C3)C4)CC1 |TLB:24:23:17.18:20| |
Structure |
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