Compile Data Set for Download or QSAR

Found 88 hits with Last Name = 'boast' and Initial = 'c'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083280 (Adamantane-1-carboxylic acid {2-[4-(2-methoxy-phen...) Show SMILES COc1ccccc1N1CCN(C[C@@H](C)NC(=O)C23C[C@H]4C[C@H](C[C@H](C4)C2)C3)CC1 |THB:23:22:19:26.24.25,23:24:19:27.22.21| Show InChI InChI=1S/C25H37N3O2/c1-18(26-24(29)25-14-19-11-20(15-25)13-21(12-19)16-25)17-27-7-9-28(10-8-27)22-5-3-4-6-23(22)30-2/h3-6,18-21H,7-17H2,1-2H3,(H,26,29)/t18-,19-,20+,21-,25?/m1/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.220	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083308 (CHEMBL555379 | Hexahydro-2,5-methano-pentalene-3a-...) Show SMILES COc1ccccc1N1CCN(CCNC(=O)C23CC4C[C@@H]2C[C@@H](C3)C4)CC1 |TLB:15:17:22:19.20.25,THB:18:17:22:19.20.25| Show InChI InChI=1S/C23H33N3O2/c1-28-21-5-3-2-4-20(21)26-10-8-25(9-11-26)7-6-24-22(27)23-15-17-12-18(16-23)14-19(23)13-17/h2-5,17-19H,6-16H2,1H3,(H,24,27)/t17-,18?,19-,23?/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.240	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50079583 ((R)-3-(3-Hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicy...) Show SMILES CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2 |TLB:13:14:20:18.17| Show InChI InChI=1S/C16H25N3OS/c1-2-3-4-5-10-21-16-15(17-7-8-18-16)20-14-12-19-9-6-13(14)11-19/h7-8,13-14H,2-6,9-12H2,1H3/t13?,14-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Binding affinity against M1 receptor was determined by displacing [3H]OXO-M in rat cortical homogenate				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083300 (Adamantane-1-carboxylic acid [(R)-1-benzyl-2-(4-py...) Show SMILES O=C(N[C@@H](CN1CCN(CC1)c1ncccn1)Cc1ccccc1)C12C[C@H]3C[C@H](C[C@H](C3)C1)C2 |TLB:31:30:33:25.26.27,31:26:33:32.30.29| Show InChI InChI=1S/C28H37N5O/c34-26(28-17-22-13-23(18-28)15-24(14-22)19-28)31-25(16-21-5-2-1-3-6-21)20-32-9-11-33(12-10-32)27-29-7-4-8-30-27/h1-8,22-25H,9-20H2,(H,31,34)/t22-,23+,24-,25-,28?/m1/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.430	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083307 (CHEMBL544163 | Hexahydro-2,5-methano-pentalene-3a-...) Show SMILES Clc1cccc(c1)N1CCN(CCNC(=O)C23CC4C[C@@H]2C[C@@H](C3)C4)CC1 |TLB:23:22:16.17:19| Show InChI InChI=1S/C22H30ClN3O/c23-19-2-1-3-20(13-19)26-8-6-25(7-9-26)5-4-24-21(27)22-14-16-10-17(15-22)12-18(22)11-16/h1-3,13,16-18H,4-12,14-15H2,(H,24,27)/t16-,17?,18-,22?/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083288 (Adamantane-1-carboxylic acid [1-benzyl-2-(4-benzyl...) Show SMILES O=C(N[C@H](CN1CCN(Cc2ccccc2)CC1)Cc1ccccc1)C12C[C@H]3C[C@H](C[C@H](C3)C1)C2 |TLB:32:31:34:26.27.28,32:27:34:33.31.30| Show InChI InChI=1S/C31H41N3O/c35-30(31-19-26-15-27(20-31)17-28(16-26)21-31)32-29(18-24-7-3-1-4-8-24)23-34-13-11-33(12-14-34)22-25-9-5-2-6-10-25/h1-10,26-29H,11-23H2,(H,32,35)/t26-,27+,28-,29?,31?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083278 (Adamantane-1-carboxylic acid {2-[4-(2-methoxy-phen...) Show SMILES Clc1cccc(c1)N1CCN(CCNC(=O)C23C[C@H]4C[C@H](C[C@H](C4)C2)C3)CC1 |THB:21:20:17:24.22.23,21:22:17:25.20.19| Show InChI InChI=1S/C23H32ClN3O/c24-20-2-1-3-21(13-20)27-8-6-26(7-9-27)5-4-25-22(28)23-14-17-10-18(15-23)12-19(11-17)16-23/h1-3,13,17-19H,4-12,14-16H2,(H,25,28)/t17-,18+,19-,23?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.890	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083277 (Adamantane-1-carboxylic acid {2-[4-(2-methoxy-phen...) Show SMILES COc1ccccc1N1CCN(CCNC(=O)C23C[C@H]4C[C@H](C[C@H](C4)C2)C3)CC1 |TLB:20:21:25:18.19.24,THB:20:19:25:26.21.22| Show InChI InChI=1S/C24H35N3O2/c1-29-22-5-3-2-4-21(22)27-10-8-26(9-11-27)7-6-25-23(28)24-15-18-12-19(16-24)14-20(13-18)17-24/h2-5,18-20H,6-17H2,1H3,(H,25,28)/t18-,19+,20-,24?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083283 (Adamantane-1-carboxylic acid {3-[4-(2-methoxy-phen...) Show SMILES COc1ccccc1N1CCN(CCCNC(=O)C23C[C@H]4C[C@H](C[C@H](C4)C2)C3)CC1 |TLB:25:24:27:19.20.21,25:20:27:26.24.23| Show InChI InChI=1S/C25H37N3O2/c1-30-23-6-3-2-5-22(23)28-11-9-27(10-12-28)8-4-7-26-24(29)25-16-19-13-20(17-25)15-21(14-19)18-25/h2-3,5-6,19-21H,4,7-18H2,1H3,(H,26,29)/t19-,20+,21-,25?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083309 (Adamantane-1-carboxylic acid [(S)-1-benzyl-2-(4-py...) Show SMILES O=C(N[C@H](CN1CCN(CC1)c1ncccn1)Cc1ccccc1)C12C[C@H]3C[C@H](C[C@H](C3)C1)C2 |TLB:31:30:33:25.26.27,31:26:33:32.30.29| Show InChI InChI=1S/C28H37N5O/c34-26(28-17-22-13-23(18-28)15-24(14-22)19-28)31-25(16-21-5-2-1-3-6-21)20-32-9-11-33(12-10-32)27-29-7-4-8-30-27/h1-8,22-25H,9-20H2,(H,31,34)/t22-,23+,24-,25?,28?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083287 (Adamantane-1-carboxylic acid [2-(4-pyrimidin-2-yl-...) Show SMILES O=C(NCCN1CCN(CC1)c1ncccn1)C12C[C@H]3C[C@H](C[C@H](C3)C1)C2 |TLB:20:21:25:18.19.24,THB:20:19:25:26.21.22| Show InChI InChI=1S/C21H31N5O/c27-19(21-13-16-10-17(14-21)12-18(11-16)15-21)22-4-5-25-6-8-26(9-7-25)20-23-2-1-3-24-20/h1-3,16-18H,4-15H2,(H,22,27)/t16-,17+,18-,21?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083286 (1-Adamantan-1-yl-3-{3-[4-(2-methoxy-phenyl)-pipera...) Show SMILES COc1ccccc1N1CCN(CCCNC(=O)NC23C[C@H]4C[C@H](C[C@H](C4)C2)C3)CC1 |TLB:26:25:28:21.20.22,26:21:28:25.27.24,18:19:24:21.26.22,THB:18:19:25.26.24:22,27:19:25.26.24:22,20:19:24:21.26.22| Show InChI InChI=1S/C25H38N4O2/c1-31-23-6-3-2-5-22(23)29-11-9-28(10-12-29)8-4-7-26-24(30)27-25-16-19-13-20(17-25)15-21(14-19)18-25/h2-3,5-6,19-21H,4,7-18H2,1H3,(H2,26,27,30)/t19-,20+,21-,25?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083291 (Adamantane-1-carboxylic acid [(R)-1-methyl-2-(4-py...) Show SMILES C[C@H](CN1CCN(CC1)c1ncccn1)NC(=O)C12C[C@H]3C[C@H](C[C@H](C3)C1)C2 |TLB:25:24:27:19.20.21,25:20:27:26.24.23| Show InChI InChI=1S/C22H33N5O/c1-16(15-26-5-7-27(8-6-26)21-23-3-2-4-24-21)25-20(28)22-12-17-9-18(13-22)11-19(10-17)14-22/h2-4,16-19H,5-15H2,1H3,(H,25,28)/t16-,17-,18+,19-,22?/m1/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50079583 ((R)-3-(3-Hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicy...) Show SMILES CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2 |TLB:13:14:20:18.17| Show InChI InChI=1S/C16H25N3OS/c1-2-3-4-5-10-21-16-15(17-7-8-18-16)20-14-12-19-9-6-13(14)11-19/h7-8,13-14H,2-6,9-12H2,1H3/t13?,14-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Affinity towards human M1 receptor expressed in CHO cells using [3H]QNB as radioligand				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083284 (Adamantane-1-carboxylic acid [1-benzyl-2-(4-benzyl...) Show SMILES O=C(N[C@@H](CN1CCN(Cc2ccccc2)CC1)Cc1ccccc1)C12C[C@H]3C[C@H](C[C@H](C3)C1)C2 |TLB:32:31:34:26.27.28,32:27:34:33.31.30| Show InChI InChI=1S/C31H41N3O/c35-30(31-19-26-15-27(20-31)17-28(16-26)21-31)32-29(18-24-7-3-1-4-8-24)23-34-13-11-33(12-14-34)22-25-9-5-2-6-10-25/h1-10,26-29H,11-23H2,(H,32,35)/t26-,27+,28-,29-,31?/m1/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083275 (CHEMBL543927 | Hexahydro-2,5-methano-pentalene-3a-...) Show SMILES O=C(NCCN1CCN(CC1)c1ncccn1)C12CC3C[C@@H]1C[C@@H](C2)C3 |TLB:1:17:22:19.20.25,THB:18:17:22:19.20.25| Show InChI InChI=1S/C20H29N5O/c26-18(20-13-15-10-16(14-20)12-17(20)11-15)21-4-5-24-6-8-25(9-7-24)19-22-2-1-3-23-19/h1-3,15-17H,4-14H2,(H,21,26)/t15-,16?,17-,20?/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083268 (Adamantane-1-carboxylic acid 2-[4-(2-methoxy-pheny...) Show SMILES COc1ccccc1N1CCN(CCOC(=O)C23C[C@H]4C[C@H](C[C@H](C4)C2)C3)CC1 |TLB:24:23:26:18.19.20,24:19:26:25.23.22| Show InChI InChI=1S/C24H34N2O3/c1-28-22-5-3-2-4-21(22)26-8-6-25(7-9-26)10-11-29-23(27)24-15-18-12-19(16-24)14-20(13-18)17-24/h2-5,18-20H,6-17H2,1H3/t18-,19+,20-,24?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083282 (CHEMBL558411 | Hexahydro-2,5-methano-pentalene-3a-...) Show SMILES COc1ccccc1N1CCN(CCCNC(=O)C23CC4C[C@@H]2C[C@@H](C3)C4)CC1 |TLB:16:18:23:20.21.26,THB:19:18:23:20.21.26| Show InChI InChI=1S/C24H35N3O2/c1-29-22-6-3-2-5-21(22)27-11-9-26(10-12-27)8-4-7-25-23(28)24-16-18-13-19(17-24)15-20(24)14-18/h2-3,5-6,18-20H,4,7-17H2,1H3,(H,25,28)/t18-,19?,20-,24?/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50079583 ((R)-3-(3-Hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicy...) Show SMILES CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2 |TLB:13:14:20:18.17| Show InChI InChI=1S/C16H25N3OS/c1-2-3-4-5-10-21-16-15(17-7-8-18-16)20-14-12-19-9-6-13(14)11-19/h7-8,13-14H,2-6,9-12H2,1H3/t13?,14-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Binding affinity towards human muscarinic M2 receptor				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083276 (CHEMBL553514 | N-{3-[4-(2-Methoxy-phenyl)-piperazi...) Show SMILES COc1ccccc1N1CCN(CCCNC(=O)CC23C[C@H]4C[C@H](C[C@](C)(C4)C2)C3)CC1 |TLB:26:25:20:23.29.22,THB:24:25:20:23.29.22,24:23:20:25.28.27| Show InChI InChI=1S/C27H41N3O2/c1-26-15-21-14-22(16-26)18-27(17-21,20-26)19-25(31)28-8-5-9-29-10-12-30(13-11-29)23-6-3-4-7-24(23)32-2/h3-4,6-7,21-22H,5,8-20H2,1-2H3,(H,28,31)/t21-,22+,26-,27?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	4.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083304 ((2S,6aR)-Hexahydro-2,5-methano-pentalene-3a-carbox...) Show SMILES COc1ccccc1N1CCN(CCOC(=O)C23CC4C[C@@H]2C[C@@H](C3)C4)CC1 |TLB:15:17:22:19.20.25,THB:18:17:22:19.20.25| Show InChI InChI=1S/C23H32N2O3/c1-27-21-5-3-2-4-20(21)25-8-6-24(7-9-25)10-11-28-22(26)23-15-17-12-18(16-23)14-19(23)13-17/h2-5,17-19H,6-16H2,1H3/t17-,18?,19-,23?/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	4.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50079583 ((R)-3-(3-Hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicy...) Show SMILES CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2 |TLB:13:14:20:18.17| Show InChI InChI=1S/C16H25N3OS/c1-2-3-4-5-10-21-16-15(17-7-8-18-16)20-14-12-19-9-6-13(14)11-19/h7-8,13-14H,2-6,9-12H2,1H3/t13?,14-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	5.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Affinity towards human M1 receptor expressed in CHO cells using [3H]QNB as radioligand				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083299 (1-Adamantan-1-yl-3-[3-(4-pyrimidin-2-yl-piperazin-...) Show SMILES O=C(NCCCN1CCN(CC1)c1ncccn1)NC12C[C@H]3C[C@H](C[C@H](C3)C1)C2 |TLB:22:23:27:21.20.26,THB:22:21:27:23.28.24| Show InChI InChI=1S/C22H34N6O/c29-21(26-22-14-17-11-18(15-22)13-19(12-17)16-22)25-5-2-6-27-7-9-28(10-8-27)20-23-3-1-4-24-20/h1,3-4,17-19H,2,5-16H2,(H2,25,26,29)/t17-,18+,19-,22?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50079592 (3-(3-Hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicyclo[...) Show SMILES CCCCCCSc1nccnc1OC1CN2CCC1C2 |THB:13:14:20:18.17| Show InChI InChI=1S/C16H25N3OS/c1-2-3-4-5-10-21-16-15(17-7-8-18-16)20-14-12-19-9-6-13(14)11-19/h7-8,13-14H,2-6,9-12H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Affinity towards human M1 receptor expressed in CHO cells using [3H]QNB as radioligand				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50079592 (3-(3-Hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicyclo[...) Show SMILES CCCCCCSc1nccnc1OC1CN2CCC1C2 |THB:13:14:20:18.17| Show InChI InChI=1S/C16H25N3OS/c1-2-3-4-5-10-21-16-15(17-7-8-18-16)20-14-12-19-9-6-13(14)11-19/h7-8,13-14H,2-6,9-12H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Affinity towards human M1 receptor expressed in CHO cells using [3H]QNB as radioligand				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083271 (Adamantane-1-carboxylic acid 3-[4-(2-methoxy-pheny...) Show SMILES COc1ccccc1N1CCN(CCCOC(=O)C23C[C@H]4C[C@H](C[C@H](C4)C2)C3)CC1 |TLB:25:24:27:19.20.21,25:20:27:26.24.23| Show InChI InChI=1S/C25H36N2O3/c1-29-23-6-3-2-5-22(23)27-10-8-26(9-11-27)7-4-12-30-24(28)25-16-19-13-20(17-25)15-21(14-19)18-25/h2-3,5-6,19-21H,4,7-18H2,1H3/t19-,20+,21-,25?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	8.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083272 (Adamantane-1-carboxylic acid 2-(4-pyrimidin-2-yl-p...) Show SMILES O=C(OCCN1CCN(CC1)c1ncccn1)C12C[C@H]3C[C@H](C[C@H](C3)C1)C2 |TLB:20:21:25:18.19.24,THB:20:19:25:26.21.22| Show InChI InChI=1S/C21H30N4O2/c26-19(21-13-16-10-17(14-21)12-18(11-16)15-21)27-9-8-24-4-6-25(7-5-24)20-22-2-1-3-23-20/h1-3,16-18H,4-15H2/t16-,17+,18-,21?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	8.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083296 (CHEMBL554204 | N-Adamantan-1-yl-3-[4-(2-methoxy-ph...) Show SMILES COc1ccccc1N1CCN(CCC(=O)NC23C[C@H]4C[C@H](C[C@H](C4)C2)C3)CC1 |TLB:16:17:23.24.22:20,THB:16:17:22:19.24.20,25:17:23.24.22:20,18:17:22:19.24.20,18:19:17.26.25:22| Show InChI InChI=1S/C24H35N3O2/c1-29-22-5-3-2-4-21(22)27-10-8-26(9-11-27)7-6-23(28)25-24-15-18-12-19(16-24)14-20(13-18)17-24/h2-5,18-20H,6-17H2,1H3,(H,25,28)/t18-,19+,20-,24?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083292 (1-Adamantan-1-yl-3-{2-[4-(2-methoxy-phenyl)-pipera...) Show SMILES COc1ccccc1N1CCN(CCNC(=O)NC23C[C@H]4C[C@H](C[C@H](C4)C2)C3)CC1 |TLB:25:24:27:20.19.21,25:20:27:24.26.23,17:18:23:20.21.25,THB:17:18:21:24.23.25,26:18:21:24.23.25,19:18:23:20.21.25| Show InChI InChI=1S/C24H36N4O2/c1-30-22-5-3-2-4-21(22)28-10-8-27(9-11-28)7-6-25-23(29)26-24-15-18-12-19(16-24)14-20(13-18)17-24/h2-5,18-20H,6-17H2,1H3,(H2,25,26,29)/t18-,19+,20-,24?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083290 (CHEMBL544630 | Hexahydro-2,5-methano-pentalene-3a-...) Show SMILES Clc1cccc(c1)N1CCN(CCCNC(=O)C23CC4C[C@@H]2C[C@@H](C3)C4)CC1 |TLB:24:23:17.18:20| Show InChI InChI=1S/C23H32ClN3O/c24-20-3-1-4-21(14-20)27-9-7-26(8-10-27)6-2-5-25-22(28)23-15-17-11-18(16-23)13-19(23)12-17/h1,3-4,14,17-19H,2,5-13,15-16H2,(H,25,28)/t17-,18?,19-,23?/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50001859 ((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...) Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1 Show InChI InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083306 (CHEMBL553024 | N-{2-[4-(2-Methoxy-phenyl)-piperazi...) Show SMILES COc1ccccc1N1CCN(CCNC(=O)CC23C[C@H]4C[C@H](C[C@](C)(C4)C2)C3)CC1 |TLB:25:24:19:22.28.21,THB:23:24:19:22.28.21,23:22:19:24.27.26| Show InChI InChI=1S/C26H39N3O2/c1-25-14-20-13-21(15-25)17-26(16-20,19-25)18-24(30)27-7-8-28-9-11-29(12-10-28)22-5-3-4-6-23(22)31-2/h3-6,20-21H,7-19H2,1-2H3,(H,27,30)/t20-,21+,25-,26?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50083268 (Adamantane-1-carboxylic acid 2-[4-(2-methoxy-pheny...) Show SMILES COc1ccccc1N1CCN(CCOC(=O)C23C[C@H]4C[C@H](C[C@H](C4)C2)C3)CC1 |TLB:24:23:26:18.19.20,24:19:26:25.23.22| Show InChI InChI=1S/C24H34N2O3/c1-28-22-5-3-2-4-21(22)26-8-6-25(7-9-26)10-11-29-23(27)24-15-18-12-19(16-24)14-20(13-18)17-24/h2-5,18-20H,6-17H2,1H3/t18-,19+,20-,24?	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibitory activity against rat limbic tissue Dopamine receptor D2				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083294 ((3-Methyl-adamantan-1-yl)-acetic acid 3-[4-(2-meth...) Show SMILES COc1ccccc1N1CCN(CCCOC(=O)CC23C[C@H]4C[C@H](C[C@](C)(C4)C2)C3)CC1 |TLB:26:25:20:23.29.22,THB:24:25:20:23.29.22,24:23:20:25.28.27| Show InChI InChI=1S/C27H40N2O3/c1-26-15-21-14-22(16-26)18-27(17-21,20-26)19-25(30)32-13-5-8-28-9-11-29(12-10-28)23-6-3-4-7-24(23)31-2/h3-4,6-7,21-22H,5,8-20H2,1-2H3/t21-,22+,26-,27?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083302 (Adamantane-1-carboxylic acid {3-[4-(3-chloro-pheny...) Show SMILES Clc1cccc(c1)N1CCN(CCCNC(=O)C23C[C@H]4C[C@H](C[C@H](C4)C2)C3)CC1 |THB:22:21:18:25.23.24,22:23:18:26.21.20| Show InChI InChI=1S/C24H34ClN3O/c25-21-3-1-4-22(14-21)28-9-7-27(8-10-28)6-2-5-26-23(29)24-15-18-11-19(16-24)13-20(12-18)17-24/h1,3-4,14,18-20H,2,5-13,15-17H2,(H,26,29)/t18-,19+,20-,24?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50079584 (3-(3-Hexyloxy-pyrazin-2-yloxy)-1-aza-bicyclo[2.2.1...) Show SMILES CCCCCCOc1nccnc1OC1CN2CCC1C2 |THB:13:14:20:18.17| Show InChI InChI=1S/C16H25N3O2/c1-2-3-4-5-10-20-15-16(18-8-7-17-15)21-14-12-19-9-6-13(14)11-19/h7-8,13-14H,2-6,9-12H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Binding affinity towards human muscarinic M2 receptor				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50083300 (Adamantane-1-carboxylic acid [(R)-1-benzyl-2-(4-py...) Show SMILES O=C(N[C@@H](CN1CCN(CC1)c1ncccn1)Cc1ccccc1)C12C[C@H]3C[C@H](C[C@H](C3)C1)C2 |TLB:31:30:33:25.26.27,31:26:33:32.30.29| Show InChI InChI=1S/C28H37N5O/c34-26(28-17-22-13-23(18-28)15-24(14-22)19-28)31-25(16-21-5-2-1-3-6-21)20-32-9-11-33(12-10-32)27-29-7-4-8-30-27/h1-8,22-25H,9-20H2,(H,31,34)/t22-,23+,24-,25-,28?/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibitory activity against rat limbic tissue Dopamine receptor D2				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50083280 (Adamantane-1-carboxylic acid {2-[4-(2-methoxy-phen...) Show SMILES COc1ccccc1N1CCN(C[C@@H](C)NC(=O)C23C[C@H]4C[C@H](C[C@H](C4)C2)C3)CC1 |THB:23:22:19:26.24.25,23:24:19:27.22.21| Show InChI InChI=1S/C25H37N3O2/c1-18(26-24(29)25-14-19-11-20(15-25)13-21(12-19)16-25)17-27-7-9-28(10-8-27)22-5-3-4-6-23(22)30-2/h3-6,18-21H,7-17H2,1-2H3,(H,26,29)/t18-,19-,20+,21-,25?/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	22	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibitory activity against rat limbic tissue Dopamine receptor D2				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50079586 (3-(6-Hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicyclo[...) Show SMILES CCCCCCSc1cncc(OC2CN3CCC2C3)n1 |THB:12:13:19:17.16| Show InChI InChI=1S/C16H25N3OS/c1-2-3-4-5-8-21-16-10-17-9-15(18-16)20-14-12-19-7-6-13(14)11-19/h9-10,13-14H,2-8,11-12H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	22	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Affinity towards human M1 receptor expressed in CHO cells using [3H]QNB as radioligand				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083312 (CHEMBL539839 | Hexahydro-2,5-methano-pentalene-3a-...) Show SMILES O=C(OCCN1CCN(CC1)c1ncccn1)C12CC3C[C@@H]1C[C@@H](C2)C3 |TLB:1:17:22:19.20.25,THB:18:17:22:19.20.25| Show InChI InChI=1S/C20H28N4O2/c25-18(20-13-15-10-16(14-20)12-17(20)11-15)26-9-8-23-4-6-24(7-5-23)19-21-2-1-3-22-19/h1-3,15-17H,4-14H2/t15-,16?,17-,20?/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50083277 (Adamantane-1-carboxylic acid {2-[4-(2-methoxy-phen...) Show SMILES COc1ccccc1N1CCN(CCNC(=O)C23C[C@H]4C[C@H](C[C@H](C4)C2)C3)CC1 |TLB:20:21:25:18.19.24,THB:20:19:25:26.21.22| Show InChI InChI=1S/C24H35N3O2/c1-29-22-5-3-2-4-21(22)27-10-8-26(9-11-27)7-6-25-23(28)24-15-18-12-19(16-24)14-20(13-18)17-24/h2-5,18-20H,6-17H2,1H3,(H,25,28)/t18-,19+,20-,24?	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibitory activity against rat limbic tissue Dopamine receptor D2				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083273 (CHEMBL545563 | Hexahydro-2,5-methano-pentalene-3a-...) Show SMILES COc1ccccc1N1CCN(CCCOC(=O)C23CC4C[C@@H]2C[C@@H](C3)C4)CC1 |TLB:16:18:23:20.21.26,THB:19:18:23:20.21.26| Show InChI InChI=1S/C24H34N2O3/c1-28-22-6-3-2-5-21(22)26-10-8-25(9-11-26)7-4-12-29-23(27)24-16-18-13-19(17-24)15-20(24)14-18/h2-3,5-6,18-20H,4,7-17H2,1H3/t18-,19?,20-,24?/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	26	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083298 (2-(3-Methyl-adamantan-1-yl)-N-[2-(4-pyrimidin-2-yl...) Show SMILES C[C@]12C[C@@H]3C[C@H](C1)CC(CC(=O)NCCN1CCN(CC1)c1ncccn1)(C3)C2 |TLB:6:1:27:5.7.4,THB:6:5:27:1.28.2,0:1:27:5.7.4| Show InChI InChI=1S/C23H35N5O/c1-22-12-18-11-19(13-22)15-23(14-18,17-22)16-20(29)24-5-6-27-7-9-28(10-8-27)21-25-3-2-4-26-21/h2-4,18-19H,5-17H2,1H3,(H,24,29)/t18-,19+,22-,23?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50079584 (3-(3-Hexyloxy-pyrazin-2-yloxy)-1-aza-bicyclo[2.2.1...) Show SMILES CCCCCCOc1nccnc1OC1CN2CCC1C2 |THB:13:14:20:18.17| Show InChI InChI=1S/C16H25N3O2/c1-2-3-4-5-10-20-15-16(18-8-7-17-15)21-14-12-19-9-6-13(14)11-19/h7-8,13-14H,2-6,9-12H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Affinity towards human M1 receptor expressed in CHO cells using [3H]QNB as radioligand				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50079589 (3-(3-Hexylsulfanyl-pyrazin-2-ylsulfanyl)-1-aza-bic...) Show SMILES CCCCCCSc1nccnc1SC1CN2CCC1C2 |THB:13:14:20:18.17| Show InChI InChI=1S/C16H25N3S2/c1-2-3-4-5-10-20-15-16(18-8-7-17-15)21-14-12-19-9-6-13(14)11-19/h7-8,13-14H,2-6,9-12H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Affinity towards human M1 receptor expressed in CHO cells using [3H]QNB as radioligand				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Rattus norvegicus (rat))	BDBM50083271 (Adamantane-1-carboxylic acid 3-[4-(2-methoxy-pheny...) Show SMILES COc1ccccc1N1CCN(CCCOC(=O)C23C[C@H]4C[C@H](C[C@H](C4)C2)C3)CC1 |TLB:25:24:27:19.20.21,25:20:27:26.24.23| Show InChI InChI=1S/C25H36N2O3/c1-29-23-6-3-2-5-22(23)27-10-8-26(9-11-27)7-4-12-30-24(28)25-16-19-13-20(17-25)15-21(14-19)18-25/h2-3,5-6,19-21H,4,7-18H2,1H3/t19-,20+,21-,25?	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	35	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibitory activity against rat limbic tissue Dopamine receptor D2				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083311 (Adamantane-1-carboxylic acid [2-(4-benzyl-piperazi...) Show SMILES C[C@H](CN1CCN(Cc2ccccc2)CC1)NC(=O)C12C[C@H]3C[C@H](C[C@H](C3)C1)C2 |TLB:26:25:28:20.21.22,26:21:28:27.25.24| Show InChI InChI=1S/C25H37N3O/c1-19(17-27-7-9-28(10-8-27)18-20-5-3-2-4-6-20)26-24(29)25-14-21-11-22(15-25)13-23(12-21)16-25/h2-6,19,21-23H,7-18H2,1H3,(H,26,29)/t19-,21-,22+,23-,25?/m1/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	37	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083310 (CHEMBL542752 | N-{2-[4-(3-Chloro-phenyl)-piperazin...) Show SMILES C[C@]12C[C@@H]3C[C@H](C1)CC(CC(=O)NCCN1CCN(CC1)c1cccc(Cl)c1)(C3)C2 |TLB:9:8:6:3.2.4,28:8:6:3.2.4,THB:9:8:2:5.6.4,7:8:2:5.6.4,28:3:8.29.7:6| Show InChI InChI=1S/C25H36ClN3O/c1-24-13-19-11-20(14-24)16-25(15-19,18-24)17-23(30)27-5-6-28-7-9-29(10-8-28)22-4-2-3-21(26)12-22/h2-4,12,19-20H,5-11,13-18H2,1H3,(H,27,30)/t19-,20+,24-,25?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	38	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50083295 (Adamantan-1-yl-carbamic acid 2-[4-(2-methoxy-pheny...) Show SMILES COc1ccccc1N1CCN(CCOC(=O)NC23C[C@H]4C[C@H](C[C@H](C4)C2)C3)CC1 |TLB:25:24:27:20.19.21,25:20:27:24.26.23,17:18:23:20.25.21,THB:17:18:24.25.23:21,26:18:24.25.23:21,19:18:23:20.25.21| Show InChI InChI=1S/C24H35N3O3/c1-29-22-5-3-2-4-21(22)27-8-6-26(7-9-27)10-11-30-23(28)25-24-15-18-12-19(16-24)14-20(13-18)17-24/h2-5,18-20H,6-17H2,1H3,(H,25,28)/t18-,19+,20-,24?	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Antagonist activity against rat hippocampal tissue 5-hydroxytryptamine 1A receptor				J Med Chem 42: 5077-94 (2000) BindingDB Entry DOI: 10.7270/Q2C82B0P
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50079590 ((S)-3-(Pyrazin-2-yloxy)-1-aza-bicyclo[2.2.1]heptan...) Show SMILES C1CN2CC1[C@@H](C2)Oc1cnccn1 |THB:7:5:3:0.1| Show InChI InChI=1S/C10H13N3O/c1-4-13-6-8(1)9(7-13)14-10-5-11-2-3-12-10/h2-3,5,8-9H,1,4,6-7H2/t8?,9-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Binding affinity towards human muscarinic M2 receptor				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
					More data for this Ligand-Target Pair

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