| Reaction Details |
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 | Report a problem with these data |
| Target | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
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| Ligand | BDBM50092500 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_205063 (CHEMBL810257) |
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| IC50 | 15.6±n/a nM |
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| Citation |  Guarna, A; Machetti, F; Occhiato, EG; Scarpi, D; Comerci, A; Danza, G; Mancina, R; Serio, M; Hardy, K Benzo[c]quinolizin-3-ones: a novel class of potent and selective nonsteroidal inhibitors of human steroid 5alpha-reductase 1. J Med Chem43:3718-35 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
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| Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
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| Synonyms: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 5α-Reductase 1 (5α-R1) | S5A1_HUMAN | S5AR | SR type 1 | SRD5A1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 29472.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P18405 |
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| Residue: | 259 |
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| Sequence: | MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQE
LPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMA
IMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD
TGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWY
LRKFEEYPKFRKIIIPFLF
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| BDBM50092500 |
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| n/a |
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| Name | BDBM50092500 |
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| Synonyms: | 4,5-dimethyl-8-chloro-1,2,5,6-tetrahydro pyrido[1,2-a]quinolin-3-one | CHEMBL125442 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H16ClNO |
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| Mol. Mass. | 261.747 |
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| SMILES | CC1Cc2cc(Cl)ccc2N2CCC(=O)C(C)=C12 |t:17| |
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| Structure | 
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