| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent dopamine transporter |
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| Ligand | BDBM50094792 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_62463 (CHEMBL679936) |
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| Ki | 9.4±n/a nM |
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| Citation |  Gu, XH; Yu, H; Jacobson, AE; Rothman, RB; Dersch, CM; George, C; Flippen-Anderson, JL; Rice, KC Design, synthesis, and monoamine transporter binding site affinities of methoxy derivatives of indatraline. J Med Chem43:4868-76 (2000) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent dopamine transporter |
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| Name: | Sodium-dependent dopamine transporter |
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| Synonyms: | DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 68749.45 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P23977 |
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| Residue: | 619 |
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| Sequence: | MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQER
ETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHC
NNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLT
ACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVD
FYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSG
FVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGID
SAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAG
TSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIV
TFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDH
QLVDRGEVRQFTLRHWLLL
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| BDBM50094792 |
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| n/a |
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| Name | BDBM50094792 |
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| Synonyms: | CHEMBL543449 | [3-(3,4-Dichloro-phenyl)-5-methoxy-indan-1-yl]-methyl-amine; hydrochloride |
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| Type | Small organic molecule |
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| Emp. Form. | C17H17Cl2NO |
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| Mol. Mass. | 322.229 |
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| SMILES | CN[C@@H]1CC(c2cc(OC)ccc12)c1ccc(Cl)c(Cl)c1 |
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| Structure | 
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