Reaction Details | |||
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Target | Polyunsaturated fatty acid 5-lipoxygenase | ||
Ligand | BDBM50085168 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_86312 (CHEMBL696464) | ||
IC50 | 21±n/a nM | ||
Citation | Kolasa, T; Gunn, DE; Bhatia, P; Woods, KW; Gane, T; Stewart, AO; Bouska, JB; Harris, RR; Hulkower, KI; Malo, PE; Bell, RL; Carter, GW; Brooks, CD Heteroarylmethoxyphenylalkoxyiminoalkylcarboxylic acids as leukotriene biosynthesis inhibitors. J Med Chem43:690-705 (2000) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Polyunsaturated fatty acid 5-lipoxygenase | |||
Name: | Polyunsaturated fatty acid 5-lipoxygenase | ||
Synonyms: | 5-LO | 5-Lipo-oxygenase (5-LOX) | 5-Lipoxygenase (5-LO) | 5-Lipoxygenase (LOX) | 5-Lipoygenase | 5-lipoxygenase/FLAP | ALOX5 | Arachidonate 5-lipoxygenase | LOG5 | LOX5_HUMAN | ||
Type: | Enzyme | ||
Mol. Mass.: | 77972.74 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Recombinant protein was purified from E. coli lysate. After ammonium sulfate precipitation and subsequent steps, the supernatant (S100) was used for 5-LO activity assay. | ||
Residue: | 674 | ||
Sequence: |
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BDBM50085168 | |||
n/a | |||
Name | BDBM50085168 | ||
Synonyms: | CHEMBL163544 | {Adamantan-2-yl-[4-(quinolin-2-ylmethoxy)-phenyl]-methoxyimino}-acetic acid | ||
Type | Small organic molecule | ||
Emp. Form. | C29H30N2O4 | ||
Mol. Mass. | 470.5595 | ||
SMILES | OC(=O)\C=N\OC(C1C2CC3CC(C2)CC1C3)c1ccc(OCc2ccc3ccccc3n2)cc1 |TLB:13:8:16:12.14.11,13:12:7.8.9:16,THB:11:10:7:12.13.14,11:12:7:10.9.16,6:7:16:12.14.11,(18.19,-7.29,;18.17,-5.77,;19.52,-5,;16.84,-5,;15.51,-5.77,;14.16,-5,;12.83,-5.77,;12.83,-7.32,;11.65,-8.23,;12.07,-9.59,;13.22,-10.48,;11.58,-10.46,;11.16,-8.99,;9.9,-8.08,;12.42,-8.01,;14.04,-8.08,;14.44,-9.55,;11.51,-5,;11.51,-3.45,;10.17,-2.68,;8.85,-3.45,;7.52,-2.68,;6.19,-3.47,;4.85,-2.68,;4.84,-1.13,;3.5,-.37,;2.16,-1.15,;.82,-.37,;-.51,-1.15,;-.51,-2.71,;.82,-3.48,;2.16,-2.68,;3.5,-3.47,;8.85,-4.98,;10.17,-5.76,)| | ||
Structure |